Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Metastasis

Metastasis

Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Preventing Crohn's recurrence, Kono-S and extended mesenteric excision: network meta-analysis category.

Langenbeck's archives of surgery·2026

Same author

Operative Efficiency and Short-Term Outcomes of Robotic Transabdominal Preperitoneal Inguinal Hernia Repair: A Prospective Single-Surgeon Cohort Study.

ANZ journal of surgery·2026

Same author

Practice Patterns and Outcomes of Preoperative Mechanical Bowel Preparation and Oral Antibiotics for Restorative Elective Colorectal Surgery: Nationwide Analysis of the ACS-NSQIP Australian Data.

ANZ journal of surgery·2026

Same author

MitoEdit: A pipeline for optimizing mtDNA base editing and predicting bystander effects.

Computational and structural biotechnology journal·2026

Same author

Significance of the Pseudosac During Inguinal Hernia Repair.

ANZ journal of surgery·2026

Same author

Rare Association Between Neurofibromatosis Type 1 and Adrenocortical Carcinoma.

Clinical case reports·2026

Search research articles

Related Experiment Video

Updated: Jun 7, 2025

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer

Published on: March 6, 2018

Management of Metastatic Anal Cancer.

Joseph Do Woong Choi¹, Devansh Shah², Toufic El-Khoury³

¹Department of Colorectal Surgery, Westmead Hospital, Sydney, New South Wales 2145, Australia; Discipline of Surgery, Faculty of Medicine and Health, University of Sydney, New South Wales 2000, Australia.

Surgical Oncology Clinics of North America

|November 15, 2024

Summary

Metastatic anal squamous cell carcinoma is rare, often linked to risk factors like HPV/HIV. Treatment involves chemotherapy, with immunotherapy as a potential second-line option for improved patient outcomes.

Keywords:

Anal cancer Chemotherapy Immunotherapy Metastatic Squamous cell carcinoma

More Related Videos

Robot-assisted Total Mesorectal Excision and Lateral Pelvic Lymph Node Dissection for Locally Advanced Middle-low Rectal Cancer

Robot-assisted Total Mesorectal Excision and Lateral Pelvic Lymph Node Dissection for Locally Advanced Middle-low Rectal Cancer

Published on: February 12, 2022

Practical Considerations in Studying Metastatic Lung Colonization in Osteosarcoma Using the Pulmonary Metastasis Assay

Practical Considerations in Studying Metastatic Lung Colonization in Osteosarcoma Using the Pulmonary Metastasis Assay

Published on: March 12, 2018

Related Experiment Videos

Last Updated: Jun 7, 2025

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer

Published on: March 6, 2018

Robot-assisted Total Mesorectal Excision and Lateral Pelvic Lymph Node Dissection for Locally Advanced Middle-low Rectal Cancer

Robot-assisted Total Mesorectal Excision and Lateral Pelvic Lymph Node Dissection for Locally Advanced Middle-low Rectal Cancer

Published on: February 12, 2022

Practical Considerations in Studying Metastatic Lung Colonization in Osteosarcoma Using the Pulmonary Metastasis Assay

Practical Considerations in Studying Metastatic Lung Colonization in Osteosarcoma Using the Pulmonary Metastasis Assay

Published on: March 12, 2018

Area of Science:

Oncology
Gastroenterology

Background:

Metastatic squamous cell carcinoma of the anal canal is a rare clinical presentation.
Risk factors include human papillomavirus (HPV), human immunodeficiency virus (HIV), immunosuppression, smoking, and receptive anal intercourse.
Metastases can occur at initial diagnosis or after primary tumor chemoradiation.

Purpose of the Study:

To summarize the current understanding and management of metastatic anal squamous cell carcinoma.
To highlight the role of systemic therapy and potential future personalized treatment strategies.

Main Methods:

Review of existing literature and clinical data on metastatic anal cancer.
Analysis of current treatment paradigms, including chemotherapy and immunotherapy.
Discussion of emerging biomarkers and ongoing clinical trials.

Main Results:

Systemic chemotherapy is the primary treatment modality.
Immunotherapy is considered as a second-line treatment option.
Predictive biomarkers show promise for future personalized treatment approaches.

Conclusions:

Management of metastatic anal cancer relies on systemic therapies.
Ongoing clinical trials aim to optimize chemotherapy and immunotherapy combinations.
Personalized treatment strategies guided by biomarkers are anticipated.