Prolamin and prolamin-polysaccharide composite nanoparticles for oral drug and nutrient delivery systems: A review

Prolamin-based nanoparticles, particularly those composed of prolamin-polysaccharide composites, have garnered significant interest as oral delivery systems in recent research. This review provides a thorough analysis of the current advancements in these composite nanoparticles with prolamins derived from various cereals, including maize, wheat, sorghum, and millet, with a focus on their applications in oral drug delivery. It discusses the mechanisms by which these composites enhance nanoparticle performance, especially in terms of stability. The review also explores the differences among various prolamins and clarifies the reasons for their performance characteristics as encapsulants for nanoparticles. Additionally, it offers an in-depth examination of various preparation methods for these composite nanoparticles, such as the traditional anti-solvent method, pH-driven method, and several innovative techniques. The study highlights the physicochemical and encapsulation properties of these composite nanoparticles and underscores their novel applications, which hold promise for future use in the food and pharmaceutical sectors. The findings aim to support the integration of prolamin-polysaccharide composites into these industries, ultimately accelerating the development of new applications for these nanoparticles.