Related Experiment Video
Updated: Jul 25, 2026
10:42
A Postoperative Evaluation Guideline for Computer-Assisted Reconstruction of the Mandible
Published on: January 28, 2020
6.5K
Reconstruction of Composite Mandible Defects Using a Cellular Bone Allograft and Soft Tissue Free Flap Coverage
Kevin J Carlson1,2, Robert M Liebman3,2, Matthew J Bak2
1Division of Otolaryngology - Head and Neck Surgery, Department of Surgery, University of Wisconsin, Madison, WI, USA.
Craniomaxillofacial Trauma & Reconstruction
|November 18, 2024
Summary
Cellular bone allografts (CBAs) show promise for mandible reconstruction without autologous components. Early results indicate successful graft integration and defect management in select patients.
Area of Science:
- Oral and Maxillofacial Surgery
- Regenerative Medicine
- Biomaterials Science
Background:
- Cellular bone allografts (CBAs) are effective bone graft materials lacking autologous components.
- Their use in mandible reconstruction is not well-documented.
- This study reviews the application of CBAs in mandible defect reconstruction.
Purpose of the Study:
- To evaluate the efficacy of cellular bone allografts (CBAs) for mandible reconstruction.
- To assess graft survival and defect management in patients receiving CBAs without autologous components.
- To report on post-operative imaging findings in mandible reconstruction using CBAs.
Main Methods:
- Retrospective case series of patients undergoing mandible reconstruction.
- Utilized cellular bone allografts (CBAs) with patient-specific graft cages and free flap coverage.
- Assessed graft survival, defect management, and post-operative imaging outcomes.
Main Results:
- Five patients (ages 23-56) underwent reconstruction for defects from trauma or malignancy.
- Four patients achieved definitive defect management, with three showing bone formation on imaging.
- One patient experienced graft failure due to fistula but was successfully salvaged.
Conclusions:
- Cellular bone allografts (CBAs), without autologous components, show promising early results for mandible reconstruction.
- Combined with soft tissue free flap coverage, CBAs can be a viable option for select patients.
- Further investigation is warranted to confirm long-term outcomes.
Related Concept Videos
01:40Bone Remodeling
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
01:02Long-patch Base Excision Repair
Since the discovery of the two BER pathways, there has been a debate about how a cell chooses one pathway over the other and the factors determining this selection. Numerous in vitro experiments have pointed out multiple determinants for the sub-pathway selection. These are:
01:19Overview of Regeneration and Repair
Regeneration and repair processes are critical in healing damages caused by injury, disease, and aging. In regeneration, the damaged tissue is entirely replaced with new growth that restores the original architecture and function. In contrast, tissue repair usually results in a fixed tissue architecture involving scar formation. Scars generally do not reestablish tissue function and may also exhibit structural abnormalities at the injury site.
Regeneration
All animals have varying degrees of...
Regeneration
All animals have varying degrees of...
01:27Fractures: Bone Repair
Treatment for a fracture is based on the type of break, the bone affected, and the patient's age.
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the procedure...
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the procedure...
01:31Bone Remodeling and Repair
Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...