Recent Advances of C-S Coupling Reaction of (Hetero)Arenes by C-H Functionalization

Area of Science:

• Organic Chemistry
• Medicinal Chemistry
• Materials Science

Background:

• Organic sulfur compounds exhibit diverse biological activities and applications.
• These compounds are prevalent in natural products, pharmaceuticals, agrochemicals, and functional materials.
• Sulfur-containing compounds are increasingly used in novel synthetic transformations.

Purpose of the Study:

• To review the synthesis of (hetero)aryl sulfides via C-H bond functionalization since 2015.
• To highlight novel transformations for constructing carbon-sulfur (C-S) bonds.
• To provide an overview of advancements in the field and inspire future research.

Main Methods:

• Utilizing various organic and inorganic sulfur compounds as coupling agents.
• Employing C-H functionalization strategies for C-S bond formation.
• Focusing on reactions reported from 2015 onwards.

Main Results:

• Development of effective methods for synthesizing (hetero)aryl sulfides.
• Expansion of the scope of accessible (hetero)aryl sulfides.
• Demonstration of the utility of C-H functionalization in constructing C-S bonds.

Conclusions:

• C-H functionalization offers powerful routes to (hetero)aryl sulfides.
• These synthetic advancements are vital for accessing compounds with potential biological activity.
• Continued research in this area promises further innovation in sulfur chemistry.