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Updated: Jun 7, 2025

A Precision Medicine Tool for Measurement and Monitoring of Hemoglobin S in Sickle Cell Disease Patients Receiving Transfusion Therapy
[Sickle cell crisis: inpatient management]
Léonore Genet1, Francesco Grandoni2,3, Lorenzo Alberio2,3
1Service de médecine interne, Département de médecine, Centre hospitalier universitaire vaudois et Université de Lausanne, 1011 Lausanne.
Sickle cell anemia, a common monogenic disease, is increasing globally, including in Switzerland. Prompt management of acute events like vaso-occlusive crises is key to improving patient outcomes and life expectancy.
Area of Science:
- Hematology
- Genetics
- Internal Medicine
Context:
- Sickle cell anemia (SCA) is the most prevalent monogenic disorder worldwide.
- SCA cases are rising in Switzerland, necessitating localized management strategies.
- The disease causes regenerative anemia and severe vaso-occlusive episodes affecting multiple organs.
Purpose:
- To outline the critical importance of multidisciplinary management for acute sickle cell anemia events.
- To detail the treatment protocols for frequent acute complications, including vaso-occlusive crises and acute chest syndrome.
Summary:
- Sickle cell anemia management focuses on addressing acute events to mitigate severe health impacts.
- Treatment strategies encompass analgesia, addressing causative factors, and preventing further complications.
- Effective interventions are crucial for enhancing patient quality of life and prognosis.
Impact:
- Optimal management of acute sickle cell anemia complications can significantly improve patient survival rates.
- Reducing morbidity and mortality associated with SCA enhances long-term patient well-being.
- Multidisciplinary care is essential for improving the overall prognosis and quality of life for individuals with sickle cell anemia.
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08:23Characterization of Sickling During Controlled Automated Deoxygenation with Oxygen Gradient Ektacytometry
Published on: November 5, 2019
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