[Local and transcutaneous pharmacotherapy. Pharmacokinetic principles and clinical evaluation]

The pharmacological and pharmacokinetic postulates and preconditions for the various kinds of pharmaco-therapy (topical, systemic and transcutaneous) are presented. Taking into consideration mathematical and physical principles as well as anatomical and physiological factors, the possibilities for influencing the flow of drugs into and through the skin are described (choice of vehicle and concentrations, permeation enhancers). In the clinical part of the study, it is shown that following these guidelines can lead to new forms of therapy and to safer application of drugs and cosmetics.