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Triple threat: Sequential meningitis infections in an immunosuppressed patient with Morganella morganii,

Yasemin Çakır Kıymaz1, Eren Kıymaz2, Zekeriya Bulut2

  • 1Department of Infectious Diseases and Clinical Microbiology, Sivas Cumhuriyet University Faculty of Medicine, Sivas, Turkey.

Diagnostic Microbiology and Infectious Disease
|November 23, 2024
PubMed

Insights

This case study highlights rare bacterial meningitis infections caused by Gram-negative bacilli and vancomycin-resistant enterococci (VRE) in an immunosuppressed patient. Successful treatment was achieved with prolonged antibiotic therapy.

Area of Science:

  • Infectious Diseases
  • Microbiology
  • Oncology

Background:

  • Bacterial meningitis is a serious infection, with Gram-negative bacilli and vancomycin-resistant enterococci (VRE) being uncommon yet challenging pathogens.
  • Immunosuppression, particularly in patients with diffuse large B-cell lymphoma, increases susceptibility to opportunistic infections.

Observation:

  • A 65-year-old male with diffuse large B-cell lymphoma presented with three distinct episodes of meningitis.
  • The causative agents identified were Morganella morganii, Acinetobacter species, and VRE, reflecting a complex infectious process.

Findings:

  • The patient experienced successive meningitis episodes caused by different rare pathogens.
  • Successful clinical and microbiological outcomes were achieved despite the challenging nature of the infections.

Implications:

  • This case underscores the importance of considering unusual pathogens in immunosuppressed patients with meningitis.
  • Effective management requires prolonged and tailored antibiotic strategies for successful patient recovery.
Keywords:
Acinetobacter baumaniMeningitisMorganella morganiiVancomycin-Resistant Enterococci

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