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Published on: March 1, 2024
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EFFECTIVENESS AND TOLERABILITY OF APREMILAST IN TREATMENT OF A SAMPLE OF PATIENTS WITH PSORIASIS.
11Department of Medicine, College of Medicine, University of AL-Qadisiyah, Iraq.
Georgian Medical News
|November 24, 2024
Summary
Apremilast significantly reduced Psoriasis Area and Severity Index (PASI) scores in Iraqi patients over six months, demonstrating good tolerability. Further multi-center research is recommended for broader validation.
Area of Science:
- Dermatology
- Pharmacology
Background:
- Psoriasis is a chronic inflammatory skin condition.
- Apremilast is an oral treatment option for moderate to severe psoriasis.
Purpose of the Study:
- To evaluate the effectiveness and tolerability of apremilast in Iraqi psoriasis patients.
- To assess changes in Psoriasis Area and Severity Index (PASI) scores.
Main Methods:
- Prospective cross-sectional study involving 125 Iraqi patients.
- Treatment with apremilast 30 mg/day for six months.
- PASI scoring system used for efficacy assessment.
Main Results:
- Significant reduction in mean PASI score from 20.37 at baseline to 3.72 after six months (p<0.001).
- Apremilast demonstrated effectiveness in improving psoriasis severity.
Conclusions:
- Apremilast is effective and well-tolerated for treating psoriasis in the studied Iraqi population.
- Multi-center studies are needed to confirm efficacy and safety in a larger Iraqi cohort.
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