Atrial fibrillation and prediabetes: Interplay between left atrium and systemic diseases

Related Experiment Video

Updated: Jun 6, 2025

Estimating Bilateral Atrial Function by Cardiovascular Magnetic Resonance Feature Tracking in Patients with Paroxysmal Atrial Fibrillation
08:10

Estimating Bilateral Atrial Function by Cardiovascular Magnetic Resonance Feature Tracking in Patients with Paroxysmal Atrial Fibrillation

Published on: July 20, 2022

1.6K

Ming-Jui Hung1

  • 1Department of Internal Medicine, Section of Cardiovascular Imaging, Division of Cardiology, Chang Gung Memorial Hospital at Keelung, Chang Gung University College of Medicine, Keelung 204201, Taiwan. miran888@ms61.hinet.net.

World Journal of Diabetes
|November 25, 2024
PubMed

Insights

Atrial fibrillation (AF) and prediabetes share common causes like inflammation. While prediabetes may worsen outcomes in AF patients, more research is needed to understand their complex relationship and guide treatment.

Area of Science:

  • Cardiology
  • Endocrinology
  • Pathophysiology

Background:

  • Atrial fibrillation (AF) frequently co-occurs with other conditions (multimorbidity).
  • Prediabetes is a common comorbidity in AF patients, sharing pathophysiological pathways such as oxidative stress and inflammation.
  • Existing data on the impact of prediabetes on AF patient outcomes are inconsistent.

Purpose of the Study:

  • To explore the intricate relationship between atrial fibrillation and prediabetes.
  • To investigate the shared pathophysiological mechanisms linking AF and prediabetes.
  • To highlight the need for further clinical studies clarifying interactions and causal links.

Main Methods:

  • Review of existing literature on AF and prediabetes.
  • Analysis of shared pathophysiological mechanisms (oxidative stress, inflammation).
  • Identification of knowledge gaps in current clinical understanding.

Main Results:

  • Shared mechanisms of oxidative stress and inflammation link AF and prediabetes.
  • Prediabetes may negatively influence major adverse cardiac or cerebrovascular events in hospitalized AF patients.
  • Inconsistent information exists regarding the precise interactions and clinical impact.

Conclusions:

  • Further in-depth research into the pathophysiology of AF and prediabetes is warranted.
  • Comprehensive prospective studies are needed to elucidate the timing of events and optimize treatment strategies.
  • Clarifying the causal relationships between AF and prediabetes is crucial for clinical practice.

Keywords:
Atrial fibrillationEndothelial dysfunctionInflammationPrediabetesStroke

More Related Videos

Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation28:13

Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation

Published on: February 26, 2013

33.3K
The WATCHMAN Left Atrial Appendage Closure Device for Atrial Fibrillation23:33

The WATCHMAN Left Atrial Appendage Closure Device for Atrial Fibrillation

Published on: February 28, 2012

83.5K

Related Concept Videos

Mitral Stenosis I: Introduction01:22

Mitral Stenosis I: Introduction

Mitral Valve Stenosis (MVS) is a heart condition where the mitral valve narrows, impeding blood circulation from the left atrium to the left ventricle. The etiology and pathophysiology of this condition are multifaceted, leading to a cascade of cardiovascular complications.Causes of Mitral Valve StenosisRheumatic Heart Disease: It is the main cause of mitral valve stenosis, particularly in developing nations. This condition arises from rheumatic fever, an inflammatory illness resulting from...
2
Pathophysiology of Diabetes01:20

Pathophysiology of Diabetes

Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
868
Imbalances in Cardiac Output01:26

Imbalances in Cardiac Output

The heart's primary function is to pump blood throughout the body, maintaining a balance between blood sent out (cardiac output) and blood returning (venous return). If this balance is disrupted, it can result in congestive heart failure (CHF), a severe condition where the heart becomes an inefficient pump, leading to inadequate blood circulation.
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send...
1.3K
Disturbances in Heart Rhythm01:28

Disturbances in Heart Rhythm

Arrhythmia or dysrhythmia refers to an abnormal heart rhythm caused by a defect in the heart's conduction system. It can cause the heart to beat irregularly, too quickly, or too slowly, leading to symptoms like chest pain, shortness of breath, and fainting. Factors such as stress, caffeine, alcohol, nicotine, cocaine, certain drugs, congenital defects, diseases, and electrolyte abnormalities can trigger arrhythmias.
Arrhythmias are categorized by their speed, rhythm, and origin. A slow...
907
Rheumatic Heart Disease I: Introduction01:23

Rheumatic Heart Disease I: Introduction

Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
3
Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies01:22

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies

The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
7