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Retrospective Analysis of Aseptic Meningitis in Kikuchi-Fujimoto Disease

Ran Cheng1, Fei Lin1, Ming Lu2

  • 1Department of Infectious Diseases, Peking University Third Hospital, Beijing, People's Republic of China.

Journal of Inflammation Research
|November 26, 2024
PubMed
Abstract

Insights

Kikuchi-Fujimoto disease (KFD) is a lymph node condition. KFD with aseptic meningitis is rare but has a good prognosis, often responding well to NSAIDs without corticosteroids.

Area of Science:

  • Immunology
  • Neurology
  • Pathology

Background:

  • Kikuchi-Fujimoto disease (KFD) is a rare, self-limiting disorder primarily affecting lymph nodes.
  • KFD concurrent with aseptic meningitis presents diagnostic challenges.

Purpose of the Study:

  • To elucidate the clinical features of KFD.
  • To determine treatment outcomes for KFD, especially in patients with aseptic meningitis.

Main Methods:

  • Retrospective observational study of 103 KFD patients diagnosed between 2013 and 2024.
  • Diagnosis confirmed by lymph node biopsy histology.
  • Analysis of clinical manifestations, laboratory findings, and treatment responses.

Main Results:

  • Common symptoms include fever, cervical pain, fatigue, and headache.
  • Elevated LDH and ferritin levels were observed in a significant proportion of patients.
  • Aseptic meningitis was confirmed in four patients with headache, all responding well to NSAIDs.

Conclusions:

  • KFD presents with diverse clinical and biological signs.
  • Aseptic meningitis in KFD cases shows a favorable prognosis, particularly with NSAID treatment.
Keywords:
Kikuchi–Fujimoto diseaseaseptic meningitishistiocytic necrotizing lymphadenitisself-limiting

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