Related Experiment Video
Updated: Jun 6, 2025
06:46
Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery
Published on: September 27, 2024
218
Factors Affecting Cancer Mortality in Young Adults: Findings from a Prospective Cohort Study
Ngoan T Le1,2, Yen T-H Pham3,4, Linh T Le5
1Institute of Research and Development, Duy Tan University, Da Nang 550000, Vietnam.
Cancers
|November 27, 2024
Summary
Cancer deaths are rising in young adults, especially in Vietnam. Family history, smoking, and alcohol increase risk, while coffee may protect against cancer deaths in this demographic.
Area of Science:
- Epidemiology
- Oncology
- Public Health
Background:
- Cancer incidence is increasing in adults aged 15-49.
- Risk factors for cancer mortality in young adults are not well understood, particularly in LMICs.
Purpose of the Study:
- To identify risk factors for cancer-related deaths in young adults in Northern Vietnam.
- To analyze the association between lifestyle factors and cancer mortality in a Vietnamese cohort.
Main Methods:
- Analysis of data from the Hanoi Prospective Cohort Study (39,401 participants, 2007-2019).
- Cox proportional hazard regression model used to calculate hazard ratios (HR) and 95% confidence intervals (95% CIs).
Main Results:
- Family history of cancer (HR=7.34), alcohol consumption (HR=1.82), and smoking (HR=2.22) are significant risk factors for cancer death in young adults.
- Coffee consumption (HR=0.49) showed a protective effect.
- Young males exhibit higher risks from smoking and alcohol compared to older adults.
Conclusions:
- The young Vietnamese population is vulnerable to cancer-related mortality.
- Cancer mortality in women is projected to increase rapidly in the future.
Related Concept Videos
02:59Cancer Prevention
6.1K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Some...
6.1K
01:21Cancer Survival Analysis
328
Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
328
02:20Longitudinal Research
11.9K
Sometimes we want to see how people change over time, as in studies of human development and lifespan. When we test the same group of individuals repeatedly over an extended period of time, we are conducting longitudinal research. Longitudinal research is a research design in which data-gathering is administered repeatedly over an extended period of time. For example, we may survey a group of individuals about their dietary habits at age 20, retest them a decade later at age 30, and then again...
11.9K
01:15Assumptions of Survival Analysis
97
Survival models analyze the time until one or more events occur, such as death in biological organisms or failure in mechanical systems. These models are widely used across fields like medicine, biology, engineering, and public health to study time-to-event phenomena. To ensure accurate results, survival analysis relies on key assumptions and careful study design.
97
01:20Actuarial Approach
63
The actuarial approach, a statistical method originally developed for life insurance risk assessment, is widely used to calculate survival rates in clinical and population studies. This method accounts for participants lost to follow-up or those who die from causes unrelated to the study, ensuring a more accurate representation of survival probabilities.
Consider the example of a high-risk surgical procedure with significant early-stage mortality. A two-year clinical study is conducted,...
Consider the example of a high-risk surgical procedure with significant early-stage mortality. A two-year clinical study is conducted,...
63
02:21Cancers Originate from Somatic Mutations in a Single Cell
11.6K
Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...
11.6K