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Recent Advances of PDMS In Vitro Biomodels for Flow Visualizations and Measurements: From Macro to Nanoscale
Andrews Souza1,2,3, Glauco Nobrega1,3, Lucas B Neves1,4
1MEtRICs-Mechanical Engineering and Resource Sustainability Center, Mechanical Engineering Department, University of Minho, Campus de Azurém, 4800-058 Guimarães, Portugal.
Micromachines
|November 27, 2024
Summary
Polydimethylsiloxane (PDMS) is a versatile material for biomodels in blood flow research. PDMS microfluidic devices and macroscale models advance physiological replication and disease diagnostics.
Area of Science:
- Biomaterials Science
- Fluid Dynamics
- Biomedical Engineering
Background:
- Polydimethylsiloxane (PDMS) is a widely adopted elastomeric material for microfluidic and macroscale in vitro models.
- Its properties make it suitable for simulating physiological environments, particularly in blood flow studies.
Purpose of the Study:
- To review recent advancements in bioflow studies utilizing PDMS microfluidic devices and macroscale biomodels.
- To highlight the application of PDMS in replicating physiological conditions and validating numerical simulations.
Main Methods:
- Review of current literature on PDMS-based biomodels in bioflow research.
- Analysis of applications in microfluidic cell deformation studies and macroscale arterial models.
Main Results:
- PDMS microchannels enable studies of blood cell deformation, distinguishing healthy from diseased cells.
- PDMS is crucial for creating patient-specific arterial models, including those with aneurysms.
- Emerging applications include nanofluid hemodynamics and nanoparticle drug delivery in organ-on-a-chip systems.
Conclusions:
- PDMS is a key material in advancing bioflow research, from microscale cell analysis to macroscale physiological modeling.
- Its versatility supports diverse applications, including disease diagnostics and drug delivery platforms.
- Further research into PDMS properties and fabrication methods will expand its role in micro- and nanoscale flow studies.
