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Immune Alterations with Aging: Mechanisms and Intervention Strategies
Weiru Yu1, Yifei Yu1, Siyuan Sun1
1Key Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health, China Agricultural University, Beijing 100083, China.
Nutrients
|November 27, 2024
Summary
Aging weakens the immune system (immunosenescence), increasing disease risk. Interventions like diet and therapies can boost immunity and reduce age-related inflammation.
Area of Science:
- Immunology
- Gerontology
- Public Health
Background:
- Aging involves complex physical, environmental, and social factors, increasing chronic disease prevalence.
- The aging immune system exhibits declines in innate and adaptive immunity, known as immunosenescence.
- Immunosenescence accelerates aging and disease onset, including infections, autoimmune disorders, and cancer.
Purpose of the Study:
- To review the effects and mechanisms of immunosenescence.
- To explore potential interventions to counteract immune decline in aging.
- To emphasize the interplay between aging, immunity, and nutrition.
Main Methods:
- Literature review of aging, immunity, and intervention strategies.
- Analysis of mechanisms underlying immune system decline with age.
- Examination of dietary, pharmacological, and immunomodulatory approaches.
Main Results:
- Immunosenescence exacerbates aging and disease risk through a feedback loop.
- Interventions aim to enhance immune cell function and modulate inflammatory responses.
- Strategies can restore immune homeostasis and mitigate age-related inflammation.
Conclusions:
- Understanding immunosenescence is critical for managing age-related diseases.
- Targeting immune function offers a promising avenue for healthy aging.
- Nutritional factors play a significant role in modulating the aging immune system.
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