Chiral iodine-catalyzed asymmetric oxyamination of unactivated olefins
Gui-Ping Han1, Jia-Qi Wang1, Jing-Feng Zhao1
1Department of Chemistry, School of Pharmacy, The Air Force Medical University, 169 Changle West Road, Xi'an 710032, P. R. China. weihechem@fmmu.edu.cn.
Abstract:
In this paper, chiral aryl iodides were used for the first time to catalyze the formation of C-O and C-N bonds of inactive olefins to obtain optically active aminolactone derivatives. The reaction is compatible with various substituted alkenyl carboxylic acid substrates. This method usually shows high activity and enantioselectivity, with a yield of up to 83% and an ee of up to 99%. It is recovery and reuse of chiral aryl iodide catalyst CIC4 showed almost no loss in product yield and enantioselectivity after 3 runs.
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