User-Friendliness Evaluation of Handling pMDI with Various Add-on Devices in Asthmatic Patients

Ahmed M Abdelfattah1, Rania M Sarhan2, Yasmin M Madney2

  • 1Clinical Pharmacy Department, Faculty of Pharmacy, King Salman International University (KSIU), South Sinai, Ras Sudr, 46612, Egypt.

AAPS Pharmscitech
|November 27, 2024
PubMed

Insights

Metered-dose inhalers (pMDIs) alone are difficult for asthma patients to use correctly. Spacers significantly improve pMDI handling, with the Able and Tips Haler devices requiring fewer sessions for optimal technique.

Area of Science:

  • Respiratory Medicine
  • Pharmaceutical Technology

Background:

  • Metered-dose inhalers (pMDIs) are common asthma medications.
  • Correct inhaler technique is crucial for effective drug delivery.
  • pMDI use can be challenging for patients, leading to suboptimal treatment.

Purpose of the Study:

  • To evaluate the efficacy of pMDIs alone versus with various spacers in asthmatic patients.
  • To identify factors influencing the learning curve for correct inhaler technique.
  • To compare the ease of use and handling errors associated with different pMDI spacers.

Main Methods:

  • 150 asthmatic patients were assessed for pMDI technique without instruction.
  • Patients were then trained on using pMDIs with and without five different spacers (Aerochamber plus, Tips Haler, Able, Dispozable, Aer-8).
  • Technique was reassessed after demonstration until optimal handling was achieved; number of sessions and errors were recorded.

Main Results:

  • pMDI alone had significantly more handling errors (53.9%) at baseline compared to pMDIs with spacers.
  • Able and Tips Haler spacers required significantly fewer training sessions for optimal technique.
  • Weak correlations were found between baseline errors and patient demographics/cognitive scores.

Conclusions:

  • Spacers simplify pMDI use for asthma patients.
  • Different spacers vary in handling difficulty and effectiveness.
  • The Able spacer demonstrated the fewest handling steps and highest patient success rate without assistance.

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