Approaching Two Decades: Biomolecular Coronas and Bio-Nano Interactions

Area of Science:

• Nanomedicine
• Biomaterials Science
• Surface Chemistry

Background:

• The term "protein corona" has evolved to "biomolecular corona" (or "biocorona") to encompass all biomolecules forming on nanoparticles.
• This corona influences nanoparticle interactions within biological systems.
• Understanding the biocorona is essential for developing effective nanomedicines.

Purpose of the Study:

• To review progress in biomolecular corona research.
• To identify key research opportunities and challenges.
• To discuss the role of advanced technologies in understanding the biocorona.

Main Methods:

• Literature review and synthesis of current research.
• Highlighting studies on nonprotein corona components and lipid nanoparticles.
• Discussing the application of artificial intelligence and ex vivo models.

Main Results:

• Significant progress has been made in understanding nonprotein corona components and lipid nanoparticles.
• The role of the biocorona in endogenous organ targeting is increasingly recognized.
• Advanced analytical techniques and models are improving biocorona characterization.

Conclusions:

• Further research is needed for improved characterization and standardization of biocorona analysis.
• Artificial intelligence and ex vivo models offer promising avenues for deeper understanding.
• Optimizing nanomedicine design relies on a comprehensive understanding of the biomolecular corona.