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Surface Enhanced Raman Spectroscopy Detection of Biomolecules Using EBL Fabricated Nanostructured Substrates
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Reaction-Based SERS Probes for the Detection of Raman-Inactive Species
Hua-Ying Chen1,2, Cheng-Ye Xi2, Han-Bin Xu2
1College of Biology and Environmental Engineering, Zhejiang Shuren University, Hangzhou 310015, P. R. China.
ACS Applied Materials & Interfaces
|November 28, 2024
Summary
This review explores reaction-activated Surface-Enhanced Raman Spectroscopy (SERS) probes for detecting Raman-inactive species. This innovative strategy enhances sensitivity and selectivity for diverse applications.
Area of Science:
- Analytical Chemistry
- Spectroscopy
- Materials Science
Background:
- Surface-enhanced Raman spectroscopy (SERS) offers high sensitivity and rich molecular information.
- A major limitation is the inability to directly detect Raman-inactive species.
- Chemical reactions can be used to activate SERS signals for indirect detection.
Purpose of the Study:
- To review reaction-based SERS probes for detecting Raman-inactive species.
- To summarize design principles and probe types.
- To discuss applications and future prospects.
Main Methods:
- Review of existing literature on reaction-activated SERS probes.
- Analysis of probe design strategies.
- Examination of application areas including bioactive species, environmental pollutants, and food contaminants.
Main Results:
- Reaction-based SERS probes enable sensitive and selective detection of Raman-inactive species.
- These probes show potential in analyzing bioactive molecules, environmental toxins, and food contaminants.
- Design principles and various probe types have been identified.
Conclusions:
- Reaction-activated SERS sensing is a promising strategy for precise determination of Raman-inactive species.
- Further advancements in probe stability, reliability, and intelligence are crucial.
- This approach holds significant potential for expanding SERS applications.
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