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Updated: Jun 6, 2025

Oral Biofilm Sampling for Microbiome Analysis in Healthy Children
10:42

Oral Biofilm Sampling for Microbiome Analysis in Healthy Children

Published on: December 31, 2017

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[The characteristics of pharyngea microbiological in children with obstructive sleep apnea]

Suhui Zhu1, Zhipan Teng2

  • 1Department of Emergency，Nanjing First Hospital，Nanjing Medical University，Nanjing，210028，China.

Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi = Journal of Clinical Otorhinolaryngology Head and Neck Surgery
|November 28, 2024
PubMed

Insights

Children with obstructive sleep apnea (OSA) exhibit altered pharyngeal microbiomes, with decreased microbial richness and disrupted composition. This finding offers new insights into OSA pathogenesis and potential therapeutic targets.

Area of Science:

  • Microbiology
  • Pediatric Pulmonology
  • Genomics

Context:

  • Obstructive sleep apnea (OSA) is a common pediatric condition with complex pathogenesis.
  • The role of the pharyngeal microbiome in OSA development is not well understood.
  • Investigating microbial changes in the pharynx may reveal novel insights into OSA.

Purpose:

  • To investigate the alterations in the pharyngeal microbiome of children with OSA compared to healthy controls.
  • To identify specific bacterial taxa that are differentially abundant in children with OSA.
  • To explore the potential of the pharyngeal microbiome as a biomarker or therapeutic target for pediatric OSA.

Summary:

  • This study analyzed the pharyngeal microbiome in 20 children with OSA and 20 controls using 16S rRNA gene sequencing.
  • Results indicated significant differences in both alpha-diversity (Chao1, Observed OTUs) and beta-diversity between groups.
  • Key findings include increased abundance of Haemophilus and decreased abundance of Veillonella and Prevotella in children with OSA.

Impact:

  • The findings suggest that disruptions in the pharyngeal microbiome contribute to the pathogenesis of OSA in children.
  • This research provides a new perspective on OSA etiology, potentially leading to innovative diagnostic and therapeutic strategies.
  • Understanding the pharyngeal microbiome's role could pave the way for microbiome-based interventions for pediatric OSA.

Keywords:
childrenmicrobiomeobstructive sleep apneapharyngeal

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