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Published on: August 7, 2017
Systemic Immune Inflammation Index, Systemic Inflammation Response Index, Aggregate Index of Systemic Inflammation,
Kamile Yucel1, Sekibe Işık Disci2
1Department of Medical Biochemistry, Faculty of Medicine, KTO Karatay University, Konya, Turkey.
Insights
Systemic Inflammatory Response Index (SIRI) and Aggregate Index of Systemic Inflammation (AISI) show elevated levels in children with pneumonia. These simple, inexpensive indices demonstrate potential for early pneumonia diagnosis and treatment.
Area of Science:
- Pediatric Medicine
- Inflammation Biomarkers
- Diagnostic Tools
Background:
- Pneumonia is a leading cause of childhood illness.
- Accurate and early diagnosis is crucial for effective treatment.
- Novel inflammatory markers require evaluation for clinical utility.
Purpose of the Study:
- To assess the diagnostic value of Systemic Immune Inflammation Index (SII), Systemic Inflammatory Response Index (SIRI), Aggregate Index of Systemic Inflammation (AISI), and follistatin-like protein-1 (FSTL-1) in pediatric pneumonia.
- To compare these markers between children with pneumonia and healthy controls.
Main Methods:
- A case-control study involving 44 children with pneumonia and 45 healthy children.
- Calculation of SIRI and AISI from hemogram data.
- Measurement of FSTL-1 levels using Enzyme-Linked Immunosorbent Assay (ELISA).
Main Results:
- Significantly higher levels of white blood cells, monocytes, eosinophils, neutrophils, C-reactive protein, SIRI, and AISI were observed in the pneumonia group.
- FSTL-1 levels were higher in pneumonia patients but without statistical significance.
- Receiver Operating Characteristic (ROC) analysis indicated the highest Area Under the Curve (AUC) for SIRI (0.754) and AISI (0.713).
Conclusions:
- SIRI and AISI are significantly elevated in children with pneumonia compared to healthy controls.
- SIRI and AISI demonstrate strong diagnostic potential, evidenced by high AUC values.
- These indices offer a simple, cost-effective approach for early pneumonia diagnosis and treatment guidance.
Abstract:
This study aims to evaluate systemic immune inflammation index, systemic inflammatory response index (SIRI), aggregate index of systemic inflammation (AISI), and follistatin-like protein-1 (FSTL-1) levels in children with pneumonia and healthy controls. The study was carried out at the Seydisehir State Hospital between February 1, 2024 and June 1, 2024. The patient group included 44 children diagnosed with pneumonia and the control group included 45 healthy children without any disease. Index values obtained from hemogram data. Enzyme-linked immunosorbent assay was used to measure FSTL-1 levels. A total of 89 participants, 44 in the patient group and 45 in the healthy control group, were included in the study. White blood cells, monocyte, eosinophil, neutrophil, c-reactive protein, SIRI, and AISI levels were significantly higher in the patient group than in the control group. FSTL-1 levels were higher in the patient group, but did not differ statistically significant. The patient and control groups were compared in the receiver operating characteristics analysis, we found the highest area under curve (AUC) in the SIRI (AUC: 0.754) and AISI (AUC: 0.713) parameters. In conclusion, compared to healthy controls, SIRI and AISI levels were significantly higher in the patient group, and the highest AUC values belonged to these indices. Therefore, we believe that SIRI and AISI indices, which are inexpensive and simple tests, are useful for early diagnosis and treatment of pneumonia.
