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The Association between EPHX1 Gene Polymorphisms and Lung Cancer among Jordanian People
Tamara E Alqudah1, Said Ismail1, Dana Abdeen1
1Department of Physiology and Biochemistry, School of Medicine, University of Jordan, Amman, Jordan.
Asian Pacific Journal of Cancer Prevention : APJCP
|November 29, 2024
Summary
Genetic variations in the EPHX1 gene do not appear to increase lung cancer risk in Jordanian patients. This study found no significant association between EPHX1 polymorphisms and lung cancer susceptibility in this population.
Area of Science:
- Genetics
- Oncology
- Molecular Epidemiology
Background:
- Genetic susceptibility plays a role in lung cancer development.
- Microsomal epoxide hydrolase (EPHX1) is involved in carcinogen metabolism.
- Polymorphisms in EPHX1 may influence individual cancer risk.
Purpose of the Study:
- To investigate the association between EPHX1 gene polymorphisms and lung cancer susceptibility in Jordanian patients.
- To determine if specific EPHX1 variants are risk factors for lung cancer in this population.
Main Methods:
- A case-control study involving 108 lung cancer patients and 110 controls from Jordan.
- Polymerase chain reaction-restriction fragment-length polymorphism (PCR-RFLP) was used to identify EPHX1 polymorphisms in exons 3 and 4.
- Genotype distributions were analyzed in relation to lung cancer status, age, gender, and tobacco consumption.
Main Results:
- No significant differences in EPHX1 genotype distribution were found between lung cancer patients and controls.
- Adjusted odds ratios for common EPHX1 genotypes did not indicate an increased risk of lung cancer.
- Logistic regression analysis confirmed no association between EPHX1 polymorphisms and lung cancer development in the Jordanian population.
Conclusions:
- Common polymorphisms in the EPHX1 gene are not significantly associated with lung cancer risk in the Jordanian population.
- The findings suggest that EPHX1 variations are unlikely to be major determinants of lung cancer susceptibility in this ethnic group.
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