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Related Experiment Videos

Vater association and anorectal malformations.

R Rintala, H Lindahl, I Louhimo

    Zeitschrift Fur Kinderchirurgie : Organ Der Deutschen, Der Schweizerischen Und Der Osterreichischen Gesellschaft Fur Kinderchirurgie = Surgery in Infancy and Childhood
    |February 1, 1986
    PubMed
    Summary

    Infants with anorectal malformations and VATER association anomalies face high early mortality, often due to cardiac issues and esophageal atresia. However, long-term quality of life is comparable to other anorectal malformation patients.

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    Area of Science:

    • Pediatric Surgery
    • Congenital Anomalies
    • Genetics and Developmental Biology

    Background:

    • Anorectal malformations (ARMs) are complex congenital anomalies.
    • VATER (Vertebral, Anal, Tracheo-Esophageal, Renal, and Limb) association anomalies frequently coexist with ARMs.
    • Understanding the prognosis of ARMs with VATER association is crucial for patient management.

    Purpose of the Study:

    • To evaluate the neonatal mortality and long-term outcomes of patients with anorectal malformations and VATER association.
    • To identify factors contributing to early mortality in this patient cohort.
    • To compare the long-term quality of life with patients having ARMs without VATER association.

    Main Methods:

    • Retrospective review of 208 patients with anorectal malformations over a 20-year period.

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  • Analysis of VATER association anomalies in 39 infants.
  • Assessment of neonatal mortality, prematurity, lethal anomalies, and urogenital malformations.

    • Main Results:

    • Neonatal mortality was 28% in VATER association patients, primarily linked to cardiac anomalies and esophageal atresia.
    • High incidence of prematurity (30%) and lethal anomalies (15%).
    • 95% of patients had urogenital malformations; 85% had high and complex anorectal anomalies.

    Conclusions:

    • Despite a grave early prognosis and extensive medical interventions, long-term outcomes and quality of life for ARM patients with VATER association are similar to those with ARMs alone.
    • Early identification and management of associated anomalies are critical for improving survival rates.