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Related Concept Videos

Acute Pyelonephritis I: Introduction01:27

Acute Pyelonephritis I: Introduction

Pyelonephritis is a bacterial infection that primarily affects the renal parenchyma and collecting system, including the renal pelvis, tubules, and interstitial tissue of one or both kidneys. It can be classified as either acute—a sudden, severe infection—or chronic, which refers to long-term or recurrent kidney infections.The primary cause of acute pyelonephritis (APN) is bacterial infection, with Escherichia coli accounting for approximately 70-80% of cases. Other bacteria, such as Proteus,...
Acute Pyelonephritis II: Diagnostic Studies and Management01:28

Acute Pyelonephritis II: Diagnostic Studies and Management

Introduction:For diagnosing acute pyelonephritis, a comprehensive patient history is collected to identify symptoms such as dysuria, frequent or urgent urination, flank pain, or costovertebral angle (CVA) tenderness that may suggest a kidney infection.Physical ExaminationDuring the physical examination, CVA tenderness is assessed. This involves gentle percussion over the costovertebral angle, where tenderness often indicates a kidney infection.Diagnostic TestsUrinalysis: Used to identify white...
Urinary Tract Calculi III: Medical Management01:30

Urinary Tract Calculi III: Medical Management

The diagnosis of renal calculi involves several imaging techniques, including non-contrast CT scans and ultrasound. These methods help visualize kidney stones, assess their size and location, and detect possible obstructions. Additionally, Measuring urine pH is useful for diagnosing specific stone types, such as struvite (alkaline pH) and uric acid stones (acidic pH). Cystine stones are primarily linked to cystinuria, a genetic condition. A urinalysis helps detect blood in the urine (hematuria)...
Urinary Tract Calculi V: Nursing Management01:28

Urinary Tract Calculi V: Nursing Management

AssessmentSubjective Data: Obtain a detailed health history, including any recent or chronic urinary tract infections, periods of immobilization, previous episodes of renal calculi, and medical conditions such as gout, benign prostatic hyperplasia, or hyperparathyroidism. Review the medication history for drugs that may influence stone formation, including allopurinol, analgesics, loop diuretics, or thiazide diuretics. Document the use of long-term indwelling catheters and any past surgical...
Acute Kidney Injury III: Clinical Manifestations01:29

Acute Kidney Injury III: Clinical Manifestations

Acute Kidney Injury (AKI) progresses through distinct clinical phases: the oliguric, diuretic, and recovery phases, each marked by unique manifestations and challenges.Oliguric Phase:The oliguric phase is the initial stage of AKI, typically lasting 10 to 14 days. This phase is marked by a significant reduction in urine output, usually less than 400 mL per day, indicating decreased kidney function. Fluid retention is a prominent feature, leading to symptoms such as edema, hypertension, and...

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Related Experiment Video

Updated: May 11, 2026

Establishment and Characterization of Three Afatinib-resistant Lung Adenocarcinoma PC-9 Cell Lines Developed with Increasing Doses of Afatinib
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[Crizotinib Associated Renal Abscess --A Case Report-].

Shohei Toyota1, Taku Kato2, Hidetoshi Ehara1

  • 1The Department of Urology, Asahi University Hospital.

Hinyokika Kiyo. Acta Urologica Japonica
|December 4, 2024
PubMed
Summary

Crizotinib treatment for metastatic lung adenocarcinoma can rarely lead to kidney complications, including polycystic lesions and renal abscesses, necessitating nephrectomy in some cases.

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Area of Science:

  • Oncology
  • Nephrology
  • Pharmacology

Background:

  • Metastatic lung adenocarcinoma with ROS-1 gene mutation is treated with crizotinib.
  • Crizotinib is an anaplastic lymphoma kinase (ALK) inhibitor used in targeted cancer therapy.

Observation:

  • A patient treated with crizotinib developed polycystic kidney lesions.
  • These lesions progressed to multiple renal abscesses, presenting with fever and elevated C-reactive protein.
  • The patient required percutaneous drainage and ultimately a left nephrectomy.

Findings:

  • Pathology confirmed renal abscesses without malignancy.
  • Crizotinib was identified as the likely cause of the renal complications.
  • This case highlights rare but serious adverse effects of crizotinib.

Implications:

  • Clinicians should be vigilant for renal adverse events in patients receiving crizotinib.
  • Early detection and management of crizotinib-induced nephrotoxicity are crucial.
  • Further research into the mechanisms of crizotinib-associated renal pathology is warranted.