Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Magnetic Resonance Imaging01:24

Magnetic Resonance Imaging

4.9K
Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...
4.9K
Brain Imaging01:14

Brain Imaging

209
Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans),  magnetic resonance imaging (MRI),  functional magnetic resonance imaging (fMRI), and Transcranial Magnetic...
209

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Impact of COVID-19 Infection and Vaccination on Neuromyelitis Optica Spectrum Disorder and Myelin Oligodendrocyte Glycoprotein Antibody Disease: A Narrative Review.

Journal of central nervous system disease·2026
Same author

Tobacco smoking disrupts bile acid and tryptophan metabolism in multiple sclerosis.

Multiple sclerosis (Houndmills, Basingstoke, England)·2026
Same author

Choroid plexus volume in Alzheimer's disease: A systematic review and meta-analysis.

Journal of Alzheimer's disease : JAD·2026
Same author

Slowly Expanding Lesions in Multiple Sclerosis: A Systematic Review and Meta-Analysis.

NeuroSci·2026
Same author

Serum metabolomic signatures of relapse recovery in early multiple sclerosis.

Multiple sclerosis and related disorders·2026
Same author

Cognitive performances in people with neuromyelitis optica spectrum disorder: a systematic review and meta-analysis.

Multiple sclerosis and related disorders·2025

Related Experiment Video

Updated: Jun 5, 2025

Magnetic Resonance Imaging of Multiple Sclerosis at 7.0 Tesla
08:51

Magnetic Resonance Imaging of Multiple Sclerosis at 7.0 Tesla

Published on: February 19, 2021

8.9K

Functional MRI and cognition in multiple sclerosis-Where are we now?

Farhad Mahmoudi1, Micheline McCarthy1, Flavia Nelson1

  • 1Department of Neurology, University of Miami, Miami, Florida, USA.

Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging
|December 5, 2024
PubMed
Summary

Functional MRI (fMRI) reveals how brain connectivity changes in multiple sclerosis (MS) impact cognitive function. It shows early compensatory brain activity, which later declines, offering a potential biomarker for MS-related cognitive impairment.

Keywords:
MScognitive impairmentfunctional MRIfunctional connectivitymultiple sclerosisresting‐statetask‐based

More Related Videos

A Multimodal Imaging- and Stimulation-based Method of Evaluating Connectivity-related Brain Excitability in Patients with Epilepsy
08:23

A Multimodal Imaging- and Stimulation-based Method of Evaluating Connectivity-related Brain Excitability in Patients with Epilepsy

Published on: November 13, 2016

11.1K
Measuring and Manipulating Functionally Specific Neural Pathways in the Human Motor System with Transcranial Magnetic Stimulation
09:52

Measuring and Manipulating Functionally Specific Neural Pathways in the Human Motor System with Transcranial Magnetic Stimulation

Published on: February 23, 2020

9.1K

Related Experiment Videos

Last Updated: Jun 5, 2025

Magnetic Resonance Imaging of Multiple Sclerosis at 7.0 Tesla
08:51

Magnetic Resonance Imaging of Multiple Sclerosis at 7.0 Tesla

Published on: February 19, 2021

8.9K
A Multimodal Imaging- and Stimulation-based Method of Evaluating Connectivity-related Brain Excitability in Patients with Epilepsy
08:23

A Multimodal Imaging- and Stimulation-based Method of Evaluating Connectivity-related Brain Excitability in Patients with Epilepsy

Published on: November 13, 2016

11.1K
Measuring and Manipulating Functionally Specific Neural Pathways in the Human Motor System with Transcranial Magnetic Stimulation
09:52

Measuring and Manipulating Functionally Specific Neural Pathways in the Human Motor System with Transcranial Magnetic Stimulation

Published on: February 23, 2020

9.1K

Area of Science:

  • Neuroscience
  • Radiology
  • Cognitive Science

Background:

  • Multiple sclerosis-related cognitive impairment (MSrCI) is prevalent in multiple sclerosis (MS) patients, causing significant disability.
  • Current conventional MRI lacks reliable metrics for diagnosing MSrCI.
  • Understanding neuroplasticity is crucial for explaining cognitive changes in MS.

Purpose of the Study:

  • To review the application of resting-state fMRI (rs-fMRI) and task-based fMRI (tb-fMRI) in understanding neuroplasticity in MS.
  • To explore the relationship between fMRI findings and cognitive changes in people with MS (pwMS).
  • To assess fMRI's potential as a diagnostic tool and biomarker for MSrCI.

Main Methods:

  • Systematic literature search of PubMed/Medline, Embase, Scopus, and Web of Science for recent fMRI cognitive studies in pwMS.
  • Analysis of findings from rs-fMRI studies focusing on brain connectivity and network efficiency.
  • Analysis of findings from tb-fMRI studies examining brain activation patterns and their correlation with disease progression and cognitive status.

Main Results:

  • rs-fMRI studies indicate disrupted brain connectivity and reduced network efficiency, contributing to cognitive impairment in MS.
  • tb-fMRI studies show initial increased brain activation as a compensatory mechanism, followed by decreased activation with disease progression and cognitive decline.
  • These patterns suggest a progressive exhaustion of the brain's compensatory capacity over time.

Conclusions:

  • fMRI provides valuable insights into neuroplasticity and compensatory mechanisms in MS-related cognitive impairment.
  • fMRI may serve as a diagnostic tool for MSrCI.
  • fMRI has potential as an imaging biomarker to monitor disease progression and cognitive changes in MS.