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Retinal Vascular Changes in Vitiligo: A Novel Approach Using OCTA
Kübra Özata Gündoğdu1, Emine Doğan1, Reyhan Çetinkaya2
1Sakarya University Education and Research Hospital, Department of Ophthalmology, Sakarya, Turkey.
Ocular Immunology and Inflammation
|December 5, 2024
Summary
Vitiligo patients showed reduced temporal retinal nerve fiber layer thickness. Ocular tissue changes in vitiligo require further investigation with larger studies.
Area of Science:
- Ophthalmology
- Dermatology
- Medical Imaging
Background:
- Vitiligo is an autoimmune condition causing melanocyte loss.
- Ocular tissues may be affected by vitiligo due to melanocyte presence.
Purpose of the Study:
- To detect structural and functional retinal and choroidal changes in vitiligo patients.
- Utilize optical coherence tomography (OCT) and OCT angiography (OCTA) for assessment.
Main Methods:
- Compared 30 vitiligo patients with 30 healthy controls.
- Measured central macular thickness (CMT), retinal nerve fiber layer (RNFL) thickness, choroidal thickness (CT), foveal avascular zone (FAZ) area, and vascular density (VD) using OCT and OCTA.
Main Results:
- Temporal RNFL thickness was significantly lower in vitiligo patients.
- No significant differences in CMT, other RNFL quadrants, CT, FAZ area, or superficial/deep VD between groups.
- Negative correlation found between vitiligo duration and RNFL/VD values.
Conclusions:
- Vitiligo may impact RNFL thickness, particularly in the temporal quadrant.
- No significant effect on retinal vascular density observed, contrary to expectations.
- Further research with larger, diverse populations is warranted to fully understand ocular implications of vitiligo.
