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Fully Substituted Thiophene Synthesis via (3 + 2) with Thiadiazoles

Ethan A Wappes1, Kyle S McClymont2, Xiaoying Zheng1

  • 1Department of Discovery Process Chemistry, Merck & Co., Inc., South San Francisco, California 94080, United States.

The Journal of Organic Chemistry
|December 6, 2024
PubMed
Summary

A novel Rh-catalyzed cycloaddition method provides access to highly substituted dihydrothiophenes and thiophenes. This modular strategy efficiently couples bicyclic 1,2,3 thiadiazoles with alkenes, complementing traditional synthesis approaches.

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