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Updated: Jun 5, 2025

A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion
Published on: February 2, 2021
An Unusual Case of Relapsing and Remitting Acute Kidney Injury
Lavanya S R Bhat1, Gangadhar Taduri1, Swarnalatha Guditi1
1Department of Nephrology, Nizams Institute of Medical Sciences, Hyderabad, Telangana, India.
Abstract:
Paroxysmal nocturnal haemoglobinuria (PNH), although a rare type of acquired hemolytic anemia, can be life-threatening if not diagnosed early. Kidney involvement in PNH varies from reversible acute kidney injury to irreversible chronic damage. Here, we report a case of recurrent acute kidney injury in a young male requiring renal replacement support. Repeated history of AKI with coombs negative hemolytic anemia led us to perform PNH profile after ruling out other causes. Although kidney involvement in PNH is not apparent, this case shows the importance of having a high index of suspicion which will help in preventing further episodes of AKI and thus, chronic kidney disease burden.
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