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Related Concept Videos

Allergic Reactions02:06

Allergic Reactions

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Hypersensitivities

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Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
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Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing...
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Adrenergic agonists have diverse therapeutic uses across various medical conditions and emergencies.
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Antibody Structure01:10

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Antibodies, also known as immunoglobulins (Ig), are essential players of the adaptive immune system. These antigen-binding proteins are produced by B cells and make up 20 percent of the total blood plasma by weight. In mammals, antibodies fall into five different classes, which each elicits a different biological response upon antigen binding.
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Local Anesthetics: Adverse Effects01:12

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While local anesthetics are generally safe and well-tolerated, they can occasionally cause adverse effects that vary in severity. Local anesthetics can induce toxicity at two distinct levels. They can either produce local effects through direct contact with the neural elements or be absorbed into the bloodstream from the injection site, leading to systemic effects.
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Related Experiment Video

Updated: Jun 5, 2025

Measuring Local Anaphylaxis in Mice
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Measuring Local Anaphylaxis in Mice

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Anaphylaxis.

Elissa M Abrams1,2, Waleed Alqurashi3, David A Fischer4

  • 1Division of Allergy, Department of Pediatrics, University of British Columbia, BC Children's Hospital, Vancouver, BC, Canada. elissa.abrams@gmail.com.

Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology
|December 9, 2024
PubMed
Summary
This summary is machine-generated.

Anaphylaxis is a severe allergic reaction that can be fatal. Prompt recognition and epinephrine treatment are crucial for managing anaphylaxis, alongside allergen avoidance and emergency plans.

Keywords:
Acute managementAnaphylaxisAnaphylaxis emergency planDiagnosisEpinephrineLong-term management

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Area of Science:

  • Allergy and Immunology
  • Emergency Medicine

Background:

  • Anaphylaxis is a life-threatening systemic hypersensitivity reaction.
  • Early recognition and diagnosis are often challenging for patients and healthcare providers.
  • Clinical presentations are diverse, frequently involving cutaneous symptoms like urticaria and angioedema.

Purpose of the Study:

  • To provide a comprehensive overview of anaphylaxis.
  • To detail the causes, clinical features, and diagnostic approaches.
  • To outline both acute and long-term management strategies.

Main Methods:

  • Review of current medical literature on anaphylaxis.
  • Synthesis of information on pathophysiology, clinical presentation, and diagnosis.
  • Consolidation of established treatment guidelines for acute and chronic care.

Main Results:

  • Anaphylaxis requires immediate recognition and treatment with epinephrine.
  • Cutaneous symptoms are common but presentations vary widely.
  • Effective long-term management involves allergen avoidance and emergency preparedness.

Conclusions:

  • Prompt intramuscular epinephrine is the first-line treatment for anaphylaxis and is safe even with diagnostic uncertainty.
  • Long-term care necessitates specialist evaluation, allergen avoidance, and patient education with an emergency plan.
  • Understanding the varied presentations and management is key to improving patient outcomes.