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Transient hearing loss with metrizamide.

M G Grant, K S Weiss, M A Novak

    The Laryngoscope
    |January 1, 1985
    PubMed
    Summary
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    Transient low-frequency sensorineural hearing loss occurred after metrizamide myelography and CT scans. This hearing impairment may stem from changes in inner ear fluid balance, similar to endolymphatic hydrops.

    Area of Science:

    • Neurology
    • Ophthalmology
    • Audiology

    Background:

    • Metrizamide is a contrast agent used in myelography and CT scans.
    • Sensorineural hearing loss can be transient and affect low frequencies.
    • Inner ear fluid dynamics are crucial for hearing function.

    Observation:

    • Two patients experienced temporary low-frequency sensorineural hearing loss after undergoing myelography and CT scanning with metrizamide.
    • The hearing loss was characterized by a reduction in the ability to perceive low-frequency sounds.

    Findings:

    • The study suggests that metrizamide may alter the osmotic balance between blood, cerebrospinal fluid, and inner ear fluids.
    • This osmotic shift could lead to increased stiffness of the inner ear membranes, causing hearing loss.

    Related Experiment Videos

  • The observed hearing loss shares similarities with the pathophysiology of endolymphatic hydrops.

    • Implications:

    • This research highlights a potential ototoxic side effect of metrizamide.
    • Further investigation is needed to understand the mechanisms of metrizamide-induced hearing loss.
    • Audiological monitoring may be advisable for patients undergoing procedures with metrizamide.