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The Novel HLA-C*03:656 Allele Identified by Next-Generation Sequencing
Manli Shen1, Jo-Ellen Jennemann2, Patricia Willey2
1Department of Pathology and Immunology, Washington University, St. Louis, Missouri, USA.
HLA
|December 12, 2024
Summary
A novel Human Leukocyte Antigen C allele, HLA-C*03:656, has been identified. It is distinguished from HLA-C*03:04:01:02 by a single nucleotide substitution.
Area of Science:
- Immunogenetics
- Molecular biology
Background:
- Human Leukocyte Antigen (HLA) genes are crucial for immune response.
- Polymorphisms in HLA genes contribute to diverse immune system functions and disease susceptibility.
Purpose of the Study:
- To report the characterization of a newly identified HLA-C allele.
Main Methods:
- Sequence analysis of the HLA-C gene.
Main Results:
- A novel HLA-C allele, designated HLA-C*03:656, was identified.
- This allele differs from HLA-C*03:04:01:02 by a single missense nucleotide substitution at codon 342 in exon 7.
Conclusions:
- The identification of HLA-C*03:656 expands the known HLA-C allele repertoire.
- This finding contributes to a more comprehensive understanding of HLA polymorphism.
