Related Experiment Video

Updated: Jun 5, 2025

Halogenated Agent Delivery in Porcine Model of Acute Respiratory Distress Syndrome via an Intensive Care Unit Type Device
09:36

Halogenated Agent Delivery in Porcine Model of Acute Respiratory Distress Syndrome via an Intensive Care Unit Type Device

Published on: September 24, 2020

2.7K

Inhaled sedation with sevoflurane in a critically ill pediatric patient

María Florencia Courtois1,2, Indalecio Carboni Bisso1, Ignacio Fernandez Ceballos1

  • 1Terapia Intensiva de Adultos, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina.

Medicina
|December 12, 2024
PubMed

Insights

This case study highlights inhaled sevoflurane as a safe and effective option for sedating pediatric patients in the intensive care unit when intravenous sedatives fail. It offers a new approach for difficult-to-sedate children.

Area of Science:

  • Anesthesiology
  • Pediatric Critical Care

Background:

  • Achieving adequate sedation in pediatric intensive care units (PICU) is challenging.
  • Intravenous sedatives are standard but may be insufficient for some patients.
  • Developing alternative sedation strategies is crucial for difficult-to-sedate pediatric populations.

Observation:

  • This case study details the first reported use of inhaled sevoflurane in a PICU.
  • The patient was unresponsive to conventional intravenous sedative agents.
  • Inhaled sevoflurane was administered as an alternative sedation method.

Findings:

  • Inhaled sevoflurane proved to be a safe alternative for sedation in this pediatric patient.
  • Sevoflurane was effective in achieving the desired sedation level.
  • This represents a novel application of inhaled sevoflurane in a PICU setting.

Implications:

  • Inhaled sevoflurane may offer a viable alternative for pediatric patients requiring sedation in the ICU.
  • This approach could improve patient comfort and treatment tolerance in challenging cases.
  • Further research into inhaled sevoflurane for refractory pediatric sedation is warranted.

Keywords:
inhaled anestheticsintensive care unitsinvasive ventilationpediatricssevoflurane

More Related Videos

In Vitro Method to Control Concentrations of Halogenated Gases in Cultured Alveolar Epithelial Cells04:56

In Vitro Method to Control Concentrations of Halogenated Gases in Cultured Alveolar Epithelial Cells

Published on: October 23, 2018

6.5K
Guidelines for Elective Pediatric Fiberoptic Intubation11:19

Guidelines for Elective Pediatric Fiberoptic Intubation

Published on: January 17, 2011

17.4K

Related Concept Videos

Inhalational Anesthetics: Overview01:20

Inhalational Anesthetics: Overview

Inhalation anesthetics are drugs that induce general anesthesia upon inhalation. They work by increasing the sensitivity of GABAA receptors or inhibiting NMDA receptors, leading to a decrease in central nervous system activity. The depth of anesthesia can be rapidly adjusted by changing the concentration of the inhaled gas. Some common examples of inhalational anesthetics include volatile liquids like isoflurane, desflurane, sevoflurane and gases like xenon and nitrous oxide. Isoflurane, a...
192
Parenteral Anesthetics: Overview01:24

Parenteral Anesthetics: Overview

Intravenous anesthetics are drugs administered parenterally to induce anesthesia or sedation. Propofol is a widely used agent formulated as a 1% emulsion in soybean oil, glycerol, and egg phosphatide. It induces rapid anesthesia primarily due to its rapid distribution from the bloodstream to target tissues and is metabolized in the liver. However, it can cause significant pain on injection and hypertriglyceridemia. Fospropofol, a water-based prodrug of propofol, lacks these adverse effects.
100
Stages of General Anesthesia01:22

Stages of General Anesthesia

Various sedation levels offer significant advantages in facilitating procedural interventions for patients undergoing medical or invasive surgical procedures. These levels span from anxiolysis to general anesthesia, providing a spectrum of sedative effects to cater to specific patient needs. Anxiolysis reduces anxiety and is achieved through minimal sedation, enabling patients to remain awake and responsive while feeling more at ease during the procedure. This level can benefit minor...
369
Sedatives and Hypnotics Drugs: Barbiturates01:20

Sedatives and Hypnotics Drugs: Barbiturates

Sedatives and hypnotics encompass a drug class that acts on the central nervous system (CNS) to alleviate anxiety, promote relaxation and induce sleep.These drugs function by amplifying the actions of the neurotransmitter γ-aminobutyric acid (GABA), resulting in reduced neuronal activity. Barbiturates, a subset of sedatives and hypnotics first synthesized in the late 1800s, are categorized into ultra-short, short, intermediate, and long-acting groups based on their duration of effect. A...
192
Acute Respiratory Failure-IV01:23

Acute Respiratory Failure-IV

Respiratory failure can manifest suddenly or gradually, characterized by a rapid decline in PaO2 and a rapid rise in PaCO2. This situation indicates a severe respiratory problem that may quickly become a life-threatening emergency. One of the early signs of hypoxemic Acute Respiratory Failure (ARF) is a change in mental status due to the brain's sensitivity to oxygen levels and changes in acid-base balance. Symptoms such as restlessness, confusion, and agitation suggest inadequate oxygen...
126
Acute Respiratory Failure-III01:30

Acute Respiratory Failure-III

Hypercapnic respiratory failure, also known as Type 2 or ventilatory respiratory failure, is a severe condition characterized by the body's inability to effectively remove carbon dioxide (CO2) from the bloodstream. It leads to an arterial CO2 pressure (PaCO2) exceeding 45 mmHg and a blood pH above 7.35. This situation indicates that the body's ventilatory demand, or the ventilation needed to maintain normal PaCO2 levels, surpasses its supply or the maximum gas flow achievable without...
158