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Updated: Jul 17, 2026

Methods to Investigate the Regulatory Role of Small RNAs and Ribosomal Occupancy of Plasmodium falciparum
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IMC1g knockdowns reveal malaria blood-stage alveolin functions
Annie Z Tremp1, Sadia Saeed1, Johannes T Dessens1
1Department of Infection Biology, Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, Keppel Street, London WC1E 7HT, UK.
Abstract:
Plasmodium alveolins are cytoskeletal proteins with important roles in cell shape, tensile strength, and motility of mosquito-stage ookinetes and sporozoites. Two recent studies by Cepeda Diaz et al. and Liu et al. employ inducible knockdown of the essential blood-stage-expressed alveolin IMC1g to identify new roles in merozoite intracellular survival, schizogonic cell division, and male gametogenesis.
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