Pineal Gland Activity in Advanced-Stage Pediatric Neuroblastoma Patients on 68 Ga-DOTATATE PET/CT

Neuroblastoma is the most common malignancy in infants and the most common extracranial solid tumor accounting for approximately 6% of pediatric cancer. Although surgical intervention serves as the primary treatment for early-stage disease, advanced-stage cases necessitate a variety of oncologic therapeutic approaches, including 131 I-MIBG and peptide receptor radionuclide therapy. Herein we report incidental pineal gland activity, represented in 68 Ga-DOTATATE PET/CT (SSTR-PET) in 3 pediatric patients diagnosed with stage 4 neuroblastoma, related to the physiological distribution of radiopharmaceuticals.