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Updated: Jun 5, 2025

Anaerobic Protein Purification and Kinetic Analysis via Oxygen Electrode for Studying DesB Dioxygenase Activity and Inhibition
Published on: October 3, 2018
AN OXIDATIVE DEAROMATIZATION CYCLIZATION MODEL FOR CORTISTATIN A
Mingji Dai1, Samuel J Danishefsky1,2
1Department of Chemistry, Columbia University, 3000 Broadway, New York, NY 10027.
Abstract:
The feasibility of a hypervalent iodine-mediated oxidative dearomatization/cyclization to produce the oxabicyclo[3.2.1]octene of cortistatin A has been demonstrated through a model study. An interesting tandem cyclization via a Ritter intermediate has been observed when a slightly different substrate was used.
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