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Updated: Jun 5, 2025

Synthesis and Characterization of Supramolecular Colloids
Published on: April 22, 2016
Tuning Colloidal Reactions
Ryan K Krueger1, Ella M King2,3, Michael P Brenner1,4
1School of Engineering and Applied Sciences, <a href="https://ror.org/03vek6s52">Harvard University</a>, 29 Oxford Street, Cambridge, Massachusetts 02138, USA.
Abstract:
The precise control of complex reactions is critical for biological processes, yet our inability to design for specific outcomes limits the development of synthetic analogs. Here, we leverage differentiable simulators to design nontrivial reaction pathways in colloidal assemblies. By optimizing over external structures, we achieve controlled disassembly and particle release from colloidal shells. Lastly, we characterize the role of configurational entropy in the structure via both forward calculations and optimization, inspiring new parameterizations of designed colloidal reactions.
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