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Updated: Jun 5, 2025

A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
Published on: October 4, 2019
Highly modified lanostane triterpenoids from natural fruiting bodies of Ganoderma cf. hochiminhense
Somporn Palasarn1, Wilunda Choowong1, Natthawut Wiriyathanawudhiwong2
1National Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency (NSTDA), 111 Thailand Science Park, Phahonyothin Road, Klong Luang, Pathumthani 12120, Thailand.
Abstract:
Eight previously undescribed highly modified lanostane triterpenoids, ganoboninketals G-K (1-5), ganoboninone I (6), ganoderlactone G (7), and (24E)-3,11-dioxolanosta-8,24-dien-26-oic acid (8), were isolated from natural fruiting bodies of Ganoderma cf. hochiminhense. The structures were elucidated on the basis of NMR spectroscopic and mass spectrometry data. Ganoboninketals G (1), H (2), and J (4) exhibited antimalarial activity against Plasmodium falciparum K1 (multidrug-resistant strain) with IC50 values of 17, 16, and 5.1 μM, respectively.

