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Murine Model of Controlled Cortical Impact for the Induction of Traumatic Brain Injury
Published on: August 16, 2019
Modeling healthcare demands and long-term costs following pediatric traumatic brain injury
Jared G Wiegand1, Zorays Moazzam2, Bruno P Braga3,4
1School of Public Health, University of Texas Health Science Center, Dallas, TX, United States.
Insights
Pediatric traumatic brain injury (TBI) survivors incur significant long-term healthcare costs and utilization, irrespective of initial injury severity. This study quantifies these ongoing needs for better care management.
Area of Science:
- Pediatric Traumatology
- Healthcare Economics
- Public Health
Background:
- Traumatic brain injury (TBI) is a major cause of childhood death and disability.
- Limited data exists on the long-term healthcare and financial burden for pediatric TBI patients.
Purpose of the Study:
- To describe and predict the longitudinal healthcare utilization and financial costs for children following acute inpatient treatment for TBI.
- To identify predictors of future healthcare demands and costs.
Main Methods:
- Analysis of deidentified claims data from 7,400 pediatric TBI patients (2007-2018).
- Stratification of costs, utilization, and readmissions by follow-up intervals and injury severity.
- Use of linear mixed models and linear regression to predict future healthcare needs.
Main Results:
- Patients accrued an average of 28.7 claims and $27,199 in costs within the first year post-discharge.
- 13.8% of patients were readmitted for TBI or non-TBI related causes, with severe TBI linked to higher readmission rates.
- Initial hospitalization length and non-home discharge predicted higher long-term utilization and costs.
Conclusions:
- Pediatric TBI patients require sustained healthcare and financial resources, regardless of initial injury severity.
- Findings inform clinicians, policymakers, and advocates for improved TBI care standards and resource allocation.
Introduction:
Traumatic brain injury (TBI) is a leading cause of death and disability in children, but data on the longitudinal healthcare and financial needs of pediatric patients is limited in scope and duration. We sought to describe and predict these metrics following acute inpatient treatment for TBI.
Methods:
Children surviving their initial inpatient treatment for TBI were identified from Optum's deidentified Clinformatics® Data Mart Database (2007-2018). Treatment cost, healthcare utilization, and future inpatient readmission were stratified by follow-up intervals, type of claim, and injury severity. Both TBI-related and non-TBI related future cost and healthcare utilization were explored using linear mixed models. Acute inpatient healthcare utilization metrics were analyzed and used to predict future treatment cost and healthcare demands using linear regression models.
Results:
Among 7,400 patients, the majority suffered a mild TBI (50.2%). For patients with at least one-year follow-up (67.7%), patients accrued an average of 28.7 claims and $27,199 in costs, with 693 (13.8%) readmitted for TBI or non-TBI related causes. Severe TBI patients had a greater likelihood of readmission. Initial hospitalization length of stay and discharge disposition other than home were significant positive predictors of healthcare and financial utilization at one-and five-years follow-up. Linear mixed models demonstrated that pediatric TBI patients would accrue 21.1 claims and $25,203 in cost in the first year, and 9.4 claims and $4,147 in costs every additional year, with no significant differences based on initial injury severity.
Discussion:
Pediatric TBI patients require long-term healthcare and financial resources regardless of injury severity. Our cumulative findings provide essential information to clinicians, caretakers, researchers, advocates, and policymakers to better shape standards, expectations, and management of care following TBI.

