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Radiologic and Clinical Characteristics of Stroke Patients with Covid-19: A Case-Control Study
Mine Sezgin1, Esme Ekizoğlu1, Nilufer Yeşilot1
1Istanbul University Istanbul Faculty of Medicine, Deparment of Neurology, Istanbul, Türkiye.
Noro Psikiyatri Arsivi
|December 16, 2024
Summary
COVID-19 (Coronavirus Disease 2019) patients experiencing stroke showed more frequent ischemic lesions across multiple arterial territories and increased hemorrhagic transformation. These patients also had poorer clinical outcomes and higher in-hospital mortality compared to controls.
Area of Science:
- Neurology
- Infectious Diseases
- Cardiovascular Research
Background:
- Severe infections, including COVID-19, can trigger cerebrovascular events like stroke.
- Understanding the specific neuroimaging and clinical characteristics of stroke in COVID-19 patients is crucial for effective management.
- Limited data exists on the detailed features of stroke in the context of COVID-19 infection.
Purpose of the Study:
- To analyze and define the neuroimaging and clinical features of stroke patients with confirmed COVID-19.
- To compare these features against a matched control group of stroke patients without COVID-19.
Main Methods:
- Prospective collection of demographic and clinical data from 21 COVID-19 stroke cases (StrokeCov) and 104 matched controls.
- Neuroimaging findings were evaluated by an experienced stroke neurologist.
- Comparison of clinical characteristics, stroke lesion localization, and outcomes between the StrokeCov and control groups.
Main Results:
- StrokeCov and control groups had similar demographics and cardiovascular risk factors (age, sex, diabetes, hypertension, hyperlipidemia, atrial fibrillation).
- Ischemic lesions were more frequent in multiple arterial territories and showed higher rates of hemorrhagic transformation in the StrokeCov group.
- Stroke patients with COVID-19 experienced significantly worse modified Rankin Scale (mRS) scores at discharge.
Conclusions:
- COVID-19 associated stroke (StrokeCov) is characterized by a higher likelihood of multi-territorial ischemic lesions and hemorrhagic transformation.
- Patients with stroke due to COVID-19 face poorer clinical outcomes and increased in-hospital mortality.
- These findings highlight the significant neurological impact of COVID-19 and the need for vigilant monitoring and tailored treatment strategies.
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