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Updated: Aug 16, 2026

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Injections of Lipopolysaccharide into Mice to Mimic Entrance of Microbial-derived Products After Intestinal Barrier Breach
Published on: May 2, 2018
Pattern of the primary and secondary antibody responses elicited by TNP-LPS in mice
Abstract:
Trinitrophenylated lipopolysaccharide (TNP-LPS) at high doses (30 micrograms) induces thymus-independent IgM and IgG anti-TNP responses. At low doses (0.3 microgram) it elicits only an IgM anti-TNP response. TNP-LPS primes for a secondary response of IgG type only when given at high doses (30 micrograms): this response is thymus dependent.

