Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Neurogenesis and Regeneration of Nervous Tissue

Neurogenesis and Regeneration of Nervous Tissue

In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Inflammatory monocytes constrain YAP-induced cell proliferation.

Science advances·2026

Same author

Maternal immune activation perturbs the brain epitranscriptome.

Brain, behavior, and immunity·2026

Same author

Cholestasis in Infants With Vein of Galen Malformation.

Journal of paediatrics and child health·2026

Same author

Single-cell transcriptomics of human brain disorders.

Molecular psychiatry·2026

Same author

Neuroprognostication via Radiomics and Machine Learning Following Neonatal Hypoxic-Ischemic Insult.

The Journal of pediatrics·2026

Same author

Maternal-fetal immune conflict contributes to male-specific impairments in a mouse model of neurodevelopmental disorders.

bioRxiv : the preprint server for biology·2026

Same journal

Translational profiling of Drd2-expressing populations reveals molecular heterogeneity of dentate gyrus mossy cells along the dorsoventral axis.

eNeuro·2026

Same journal

Movement Disorder Patients with Depression have Altered Corticostriatal Alpha-Beta Power Response to Reward and Loss.

eNeuro·2026

Same journal

Ocular speech tracking persists in blindness, but its dynamics and oculo-cerebral connectivity depend on visual status.

eNeuro·2026

Same journal

Emergent multidien cycles from partial circadian synchrony.

eNeuro·2026

Same journal

Adolescent social isolation induces persistent impairments in emotional discrimination and helping behavior.

eNeuro·2026

Same journal

Increased Ih Current Is Associated with Reduced Hippocampal CA1 Excitability in a Mouse Model of Multiple Sclerosis.

eNeuro·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Jun 5, 2025

A Battery of Motor Tests in a Neonatal Mouse Model of Cerebral Palsy

A Battery of Motor Tests in a Neonatal Mouse Model of Cerebral Palsy

Published on: November 3, 2016

Neonatal Brain Injury Triggers Niche-Specific Changes to Cellular Biogeography.

Nareh Tahmasian^1,2,3, Min Yi Feng^1,4, Keon Arbabi^5,6

¹Program in Neuroscience and Mental Health, SickKids Research Institute, Toronto, Ontario M5G 1L7, Canada brian.kalish@sickkids.ca.

|December 16, 2024

Summary

This summary is machine-generated.

Neonatal hypoxia causes brain injury in preterm infants. This study maps the brain

Keywords:

hypoxia neurogenesis remyelination spatial transcriptomics white matter injury

More Related Videos

Stereotactic Atlas-Guided Laser Capture Microdissection of Brain Regions Affected by Traumatic Injury

Stereotactic Atlas-Guided Laser Capture Microdissection of Brain Regions Affected by Traumatic Injury

Published on: September 11, 2017

Neurobehavioral Assessments in a Mouse Model of Neonatal Hypoxic-ischemic Brain Injury

Neurobehavioral Assessments in a Mouse Model of Neonatal Hypoxic-ischemic Brain Injury

Published on: November 24, 2017

Related Experiment Videos

Last Updated: Jun 5, 2025

A Battery of Motor Tests in a Neonatal Mouse Model of Cerebral Palsy

A Battery of Motor Tests in a Neonatal Mouse Model of Cerebral Palsy

Published on: November 3, 2016

Stereotactic Atlas-Guided Laser Capture Microdissection of Brain Regions Affected by Traumatic Injury

Stereotactic Atlas-Guided Laser Capture Microdissection of Brain Regions Affected by Traumatic Injury

Published on: September 11, 2017

Neurobehavioral Assessments in a Mouse Model of Neonatal Hypoxic-ischemic Brain Injury

Neurobehavioral Assessments in a Mouse Model of Neonatal Hypoxic-ischemic Brain Injury

Published on: November 24, 2017

Area of Science:

Neuroscience
Developmental Biology
Genomics

Background:

Preterm infants face risks of brain injury and neurodevelopmental issues due to white matter damage from chronic hypoxia.
The molecular mechanisms linking neonatal hypoxia to impaired early neurodevelopment remain unclear.

Purpose of the Study:

To create a comprehensive brain-wide map of the regenerative response to neonatal brain injury.
To investigate the molecular and cellular changes induced by chronic neonatal hypoxia in a mouse model.
To identify mechanisms of both repair and impediment in neural circuit rewiring.

Main Methods:

Utilized high-resolution imaging-based spatial transcriptomics to analyze over 800,000 cells in a mouse model.
Developed a novel method to infer condition-associated differences in cell type spatial proximity.
Analyzed region-specific cell states, cell type composition, and spatial organization.

Main Results:

Observed significant hypoxia-associated alterations in regional cell states, composition, and spatial organization.
Identified molecular mechanisms driving reparative neurogenesis and gliogenesis.
Nominated specific pathways that may hinder neural circuit rewiring after neonatal hypoxia.

Conclusions:

Provides a detailed molecular and cellular atlas of the brain's response to neonatal injury.
Offers insights into the complex interplay of repair and disruption following hypoxic brain injury.
Lays the groundwork for understanding and potentially treating neurodevelopmental impairments.