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Updated: Jun 5, 2025

Intravenous Injections in Neonatal Mice
Published on: November 11, 2014
Bemiparin in neonatal thrombosis: therapeutic dosing and safety
Maria Sanchez-Holgado1, Mercedes Sampedro2, Carlos Zozaya2
1Department of Neonatology. La Paz University Hospital, Madrid, Spain. msholgado@salud.madrid.org.
Objective:
To evaluate the therapeutic dose and safety of bemiparin in neonatal thrombosis treatment.
Study Design:
A retrospective review was conducted on infants treated with bemiparin between 2018 and 2023 at a tertiary hospital.
Results:
72 neonates with a mean gestational age of 37 weeks were included. Twenty were preterm, with a median gestational age of 33.5 weeks and a median birth weight of 1847.5 grams. The mean (SD) initial and therapeutic bemiparin doses were 170.5 (31) and 200 (37.2) IU/kg/day, respectively. Only 32% of patients reached the therapeutic target range (TTR) with the initial dose. Preterm infants required higher doses to reach TTR (215 vs 194.7 IU/kg/day, p = 0.05). Adverse events were minimal (1.4%) and unrelated to the starting dose or prematurity.
Conclusion:
Bemiparin appears to be a potential therapeutic option for anticoagulation in neonates; however, targeted anti-Xa levels were rarely achieved with the initial dose and most patients required uptitration.
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