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The Cardioprotective Effects of Nutritional Ketosis: Mechanisms and Clinical Implications

Claudia Venturini1, Lucia Mancinelli2, Giulia Matacchione3

  • 1Clinical Nutrition Unit, IRCCS INRCA, 60127 Ancona, Italy.

Nutrients
|December 17, 2024
PubMed

Insights

Nutritional ketosis, a metabolic state from low-carb diets, shows promise in protecting the heart. Ketone bodies, like beta-hydroxybutyrate (BHB), may reduce cardiovascular disease risk through anti-inflammatory effects.

Area of Science:

  • Cardiovascular research
  • Metabolic health
  • Nutritional science

Background:

  • Cardiovascular diseases (CVDs) are the leading cause of global mortality.
  • Rising rates of obesity, metabolic syndrome, and type 2 diabetes exacerbate CVD risk.
  • Novel therapeutic strategies are urgently needed to combat the CVD crisis.

Purpose of the Study:

  • To review the mechanisms by which ketone bodies mitigate cardiovascular risk.
  • To focus on the anti-inflammatory and antioxidative properties of beta-hydroxybutyrate (BHB).
  • To highlight the clinical relevance of nutritional ketosis in cardiometabolic health.

Main Methods:

  • Literature review of studies on nutritional ketosis and cardiovascular health.
  • Examination of the metabolic state of ketosis and ketone body production.
  • Focus on beta-hydroxybutyrate (BHB) as the primary ketone body.

Main Results:

  • Ketosis shifts the body's primary energy source from glucose to ketone bodies.
  • Ketone bodies, particularly BHB, exhibit anti-inflammatory and antioxidative properties.
  • Evidence suggests potential cardioprotective effects of nutritional ketosis.

Conclusions:

  • Nutritional ketosis presents a potential therapeutic strategy for reducing cardiovascular risk.
  • BHB's anti-inflammatory and antioxidative actions are key mechanisms for cardioprotection.
  • Further research is warranted to fully elucidate the clinical applications of ketosis in cardiometabolic health.

Keywords:
beta-hydroxybutyratecardiovascular riskinflammationketogenic dietobesity

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