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Related Experiment Video

Updated: Jun 4, 2025

Optimizing Extracellular Vesicle Delivery Using a Core-Sheath 3D-Bioprinted Scaffold for Chronic Wound Management

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Published on: February 28, 2025

Bioengineered Extracellular Vesicle Hydrogel Modulating Inflammatory Microenvironment for Wound Management.

Yunfei Mu¹, Liwen Ma², Jia Yao¹

¹State Key Laboratory of Organic Electronics and Information Displays, Jiangsu Key Laboratory of Smart Biomaterials and Theranostic Technology, Nanjing University of Posts and Telecommunications, Nanjing 210023, China.

International Journal of Molecular Sciences

|December 17, 2024

Summary

This study introduces a novel bioactive hydrogel patch for chronic wound healing. The patch uses engineered extracellular vesicles to reduce inflammation and promote tissue regeneration, improving healing outcomes.

Keywords:

bioactive hydrogel extracellular vesicles tissue healing

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Published on: November 17, 2023

Area of Science:

Biomaterials Science
Tissue Engineering
Immunology

Background:

Chronic wounds pose significant challenges due to persistent inflammation, infection risk, and limited therapeutic options.
Effective wound management requires strategies that address both the biological healing environment and logistical application.

Purpose of the Study:

To develop a novel bioactive hydrogel patch for enhanced chronic wound healing.
To investigate the immunomodulatory and regenerative capabilities of engineered extracellular vesicles within a hydrogel matrix.

Main Methods:

Synthesized ZIF@EV nanoparticles by encapsulating zeolitic imidazolate framework-8 (ZIF-8) into M2 macrophage-derived extracellular vesicles (EVs).
Embedded ZIF@EV nanoparticles into a sodium alginate hydrogel matrix to create a bioactive hydrogel patch.
Evaluated the hydrogel patch's efficacy in a murine model of chronic wounds, comparing it to growth factor therapies and foam dressings.

Main Results:

The hydrogel patch facilitated controlled release of therapeutic agents, stimulating endothelial cell proliferation and angiogenesis.
EV-infused patch successfully polarized macrophages to an M2 phenotype, shifting the wound microenvironment towards regeneration.
Demonstrated significant improvements in healing speed, quality, and tissue integration compared to conventional treatments.

Conclusions:

The developed bioactive hydrogel patch offers a promising, versatile, and practical solution for managing chronic wounds.
This adaptable platform addresses key biological and clinical needs in chronic wound care.
Further clinical translation of this bioengineered approach holds potential for improved patient outcomes.