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Engineering Dual Active Sites and Defect Structure in Nanozymes to Reprogram Jawbone Microenvironment for
Zheng Cheng1, Yuchen Wang1, Haobo Lin1
1Department of Oral and Maxillofacial Surgery, The Affiliated Stomatological Hospital of Nanjing Medical University, State Key Laboratory Cultivation Base of Research, Prevention and Treatment for Oral Diseases, Jiangsu Province Engineering Research Centre of Stomatological Translational Medicine, Nanjing Medical University, Nanjing, Jiangsu, 210029, China.
Iron-doped vanadium oxide (Fe-VOx) nanozymes scavenge reactive oxygen and nitrogen species (RONS) to treat osteoradionecrosis of the jaw (ORNJ). These nanozymes restore mitochondrial function, enhance mitophagy, and inhibit infection, offering a novel therapeutic strategy.
Area of Science:
- Biomaterials Science
- Nanotechnology
- Oncology
Background:
- Osteoradionecrosis of the jaw (ORNJ) affects 4-8% of head and neck cancer patients post-radiotherapy.
- Radiation-induced tissue damage is linked to overproduction of reactive oxygen and nitrogen species (RONS).
Purpose of the Study:
- To develop Fe-doped VOx (Fe-VOx) nanozymes with multi-enzyme activities for ORNJ treatment.
- To investigate the efficacy of Fe-VOx nanozymes in scavenging RONS, restoring mitochondrial function, and inhibiting infection.
Main Methods:
- Fe doping of VOx nanozymes to create defects like Fe substitution and oxygen vacancies (OVs).
- Evaluation of Fe-VOx nanozymes' catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GPx) enzyme-mimicking activities.
- Assessment of Fe-VOx nanozymes' ability to reprogram the jawbone microenvironment, restore mitochondrial dysfunction, and enhance mitophagy.
- Utilizing the surface plasmon resonance (SPR) effect for photothermal therapy to inhibit jaw infection.
Main Results:
- Fe doping significantly enhanced the multi-enzyme mimicking activities of VOx nanozymes.
- Fe-VOx nanozymes effectively scavenged RONS, restored mitochondrial function, and promoted mitophagy.
- The surface plasmon resonance (SPR) effect of Fe-VOx nanozymes demonstrated potent photothermal antibacterial activity.
Conclusions:
- Fe-VOx nanozymes possess multi-enzyme activities for efficient RONS scavenging and mitophagy activation.
- Fe-VOx nanozymes show potential as photothermal agents to inhibit jaw infection.
- This study presents Fe-VOx nanozymes as a promising therapeutic candidate for treating ORNJ.
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