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Updated: Jun 4, 2025

Generation of 3D Whole Lung Organoids from Induced Pluripotent Stem Cells for Modeling Lung Developmental Biology and Disease
Published on: April 12, 2021
[Nosological aspects of the petrification and ossification processes in the lungs]
I V Dvorakovskaya1, I S Platonova1, T A Novickaya2
1Pavlov First St. Petersburg State Medical University, St. Petersburg, Russia.
Abstract:
Microscopic changes in the lung biopsies of 16 adult patients of both sexes without clear clinical symptoms are described. According to X-ray examination data, disseminated process in the lungs was diagnosed in 4 patients, interstitial pneumonia in 4, osteoplastic pneumopathy in 3, as well as tuberculosis, bronchiolitis and a number of others. Microscopic examination showed that the patients had various forms of petrification and ossification of the lungs, diagnosed clinically and radiologically in only 3 cases. The place of petrification of the lungs in nosology is discussed, from which it follows that we are talking about a violation of calcium metabolism, i.e. about dystrophy, and not about a storage disease. Petrification of the lungs as a precursor to ossification is a complication of various diseases, but not a self-sufficient nosological form.
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