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Updated: Jun 4, 2025
Antigen-Capture Enzyme-Linked Immunosorbent Assay for Specific Detection of Mycoplasma pneumoniae
Published on: February 24, 2023
Pulmonary embolism in children with mycoplasma pneumonia: can it be predicted?
Jiapu Hou1,2, Ruiyang Sun1,2, Xue Zhang1,2
1Children's Hospital Affiliated to Zhengzhou University, Zhengzhou, Henan, 450052, China.
Purpose:
To investigate the clinical characteristics of Mycoplasma pneumoniae (MP) pneumonia (MPP) combined with pulmonary embolism (PE) in children.
Methods:
291 hospitalized pediatric cases with MPP were enrolled from January 2018 to May 2024 and divided into the PE group (141 cases) and non-PE control group (150 cases). Clinical data of both groups were analyzed and compared.
Results:
C-reactive protein (CRP), D-dimer, lactate dehydrogenase (LDH), and interleukin 6 (IL-6) were significantly higher in the PE group than in the non-PE control group. There were 85 males and 56 females in the PE group. The PE group has male-to-female ratio of 3: 2,and hemoptysis was observed in 11 children (7.08%), chest pain in 29 children (20.60%), and pulmonary necrosis in 89 children (63.12%). In the receiver operator curve(ROC), the areas under the curve(AUC) for D-dimer, CRP, IL-6, and LDH were 0.964, 0.690, 0.632, and 0.765, respectively. In the ROC curve, the cutoff values for D-dimer, CRP, IL-6, and LDH were 0.8 µg/ml, 24.2 mg/L, 37.8 pg/ml, and 461 U/L, respectively.
Conclusion:
A proportion of children with MP infection combined with PE show atypical clinical symptoms. Children with MPP and elevated D-dimer levels, IL-6, CRP, erythrocyte sedimentation rate (ESR), and LDH may be prone to develop PE.
Insights
Pediatric Mycoplasma pneumoniae pneumonia (MPP) with pulmonary embolism (PE) can present with unusual symptoms. Elevated D-dimer, IL-6, CRP, and LDH levels may indicate a higher risk of PE in children with MPP.
Area of Science:
- Pediatric Pulmonology
- Infectious Diseases
- Cardiovascular Medicine
Background:
- Mycoplasma pneumoniae pneumonia (MPP) is a common childhood respiratory infection.
- Pulmonary embolism (PE) is a serious complication that can occur in children with MPP.
- Understanding the clinical characteristics of combined MPP and PE is crucial for early diagnosis and management.
Purpose of the Study:
- To investigate the clinical characteristics of pediatric Mycoplasma pneumoniae pneumonia (MPP) complicated with pulmonary embolism (PE).
- To identify potential biomarkers for predicting PE in children with MPP.
Main Methods:
- A retrospective study of 291 hospitalized pediatric cases with MPP was conducted.
- Cases were divided into a PE group (141) and a non-PE control group (150).
- Clinical data, including laboratory markers and symptoms, were analyzed and compared between the groups.
Main Results:
- The PE group exhibited significantly higher levels of C-reactive protein (CRP), D-dimer, lactate dehydrogenase (LDH), and interleukin-6 (IL-6) compared to the non-PE group.
- Key indicators for PE prediction included D-dimer (AUC=0.964), LDH (AUC=0.765), CRP (AUC=0.690), and IL-6 (AUC=0.632).
- Pulmonary necrosis was observed in 63.12% of the PE group, with hemoptysis and chest pain also noted.
Conclusions:
- Pediatric MPP with PE can manifest with atypical clinical symptoms.
- Elevated D-dimer, IL-6, CRP, and LDH levels are associated with an increased risk of PE in children with MPP.
- These findings aid in identifying high-risk pediatric patients for timely PE diagnosis and intervention.
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