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Accessory Structures of the Eye

Accessory Structures of the Eye

Optical perception, or vision, is an extraordinary sense dependent on converting light signals received via the ocular organs. These organs, known as eyes, are securely positioned within the bony cavities of the skull, called orbits. The orbits serve a dual purpose: a protective shield for the ocular globes and a stable attachment point for the soft ocular tissues. The eye's external protective mechanisms include the eyelids, which are edged with lashes that act as a barrier against foreign...

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Related Experiment Video

Updated: Jun 4, 2025

In vivo Structural Assessments of Ocular Disease in Rodent Models using Optical Coherence Tomography

In vivo Structural Assessments of Ocular Disease in Rodent Models using Optical Coherence Tomography

Published on: July 24, 2020

Advancements in Ocular Modelling and Simulations: Key Considerations and Case Studies.

Mohammed Shareef Khan¹, Aditya Murthy², Tausif Ahmed³

¹Biopharmaceutics - Biopharmaceutics and Bioequivalence, Global Clinical Management, Dr. Reddy's Laboratories Ltd, Hyderabad, India. mohammedshareefkhan@drreddys.com.

AAPS Pharmscitech

|December 17, 2024

Summary

This summary is machine-generated.

Ocular biopharmaceutics and drug delivery are optimized using ocular compartmental modeling and simulation. This approach enhances understanding of eye physiology and disease for targeted therapies.

Keywords:

GastroPlus OCAT modelling Ocular PBPK modelling (O-PBPK)Ocular drug delivery Ocular pharmacokinetics

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Last Updated: Jun 4, 2025

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Area of Science:

Ophthalmology
Pharmaceutics
Biomedical Engineering

Background:

The eye's complex structure necessitates specialized drug delivery systems.
Ocular diseases require precise therapeutic interventions.
Current ocular drug delivery methods face significant challenges.

Purpose of the Study:

To review ocular biopharmaceutics, focusing on modeling and simulation.
To explore drug delivery formulations and administration routes for ocular therapies.
To highlight the role of ocular compartmental modeling in understanding eye diseases.

Main Methods:

Comprehensive literature review of ocular biopharmaceutics.
Analysis of ocular compartmental modeling and simulation techniques.
Discussion of various ocular drug delivery formulations and administration routes.

Main Results:

Ocular compartmental modeling provides critical insights into drug distribution and release kinetics.
Understanding eye physiology is key to optimizing drug delivery.
Various formulations offer distinct advantages and limitations for ocular drug delivery.

Conclusions:

Ocular compartmental modeling and simulation are essential tools for advancing ocular drug delivery.
Targeted drug delivery strategies can be significantly improved through modeling.
This review serves as a reference for optimizing ocular therapies.