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[DPEPhosbcpCu]PF6: A General and Broadly Applicable Copper-Based Photoredox Catalyst
Published on: May 21, 2019
Copper-Catalyzed Domino Phosphorylation/Cyclization of ortho-Alkynylketones for Accessing Phosphorylated
Xiao-Hong Wei1, Xuan Liu1, Xiao-Hong Wang1
1Key Laboratory of Environment-Friendly Composite Materials of the State Ethnic Affairs Commission, Key Laboratory for Utility of Environment-Friendly Composite Materials and Biomass in University of Gansu Province, College of Chemical Engineering, College of Chemical Engineering, Northwest Minzu University, Lanzhou 730030, P. R. China.
Abstract:
An effective and economical copper-catalyzed approach for the synthesis of phosphorylated 1H-isochromenes is reported. This method is the first example of focus on ketone phosphonylation to establish a C-P bond and 6-endo-dig cyclization to construct a C-O bond between aryl- and alkyl-substituted alkynylketones and H-phosphinate esters, H-phosphites, and H-phosphine oxides, resulting in chemo- and regioselective phosphorylated 1H-isochromenes with moderate to excellent yields under smooth reaction conditions.
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