Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Cancer Survival Analysis

Cancer Survival Analysis

Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Development of a virtual phantom for HDR cervical cancer brachytherapy: A multi-institutional tool for training, quality assurance, and variability reduction.

Journal of applied clinical medical physics·2026

Same author

Nationwide genomic data analysis of central nervous system tumors in Japan based on C-CAT database.

International journal of clinical oncology·2026

Same author

Cooperative Roles of Class IA PI3K Isoforms in Translocation-Related Sarcoma Cell Survival and Proliferation.

Cancer research communications·2026

Same author

Ensuring bladder volume reproducibility and reducing cone-beam computed tomography-related radiation exposure in prostate hypofractionated radiotherapy by a Certified Nurse in Radiation Oncology nursing.

Journal of radiation research·2026

Same author

[Pneumatosis cystoides intestinalis with extensive intraperitoneal free air, retroperitoneal emphysema, and pneumomediastinum:a case report].

Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology·2026

Same author

Psychological distress and cancer worry in unaffected relatives undergoing cascade testing with multigene panel testing.

Journal of human genetics·2026

Search research articles

Related Experiment Video

Updated: May 2, 2026

Radiation Planning Assistant - A Streamlined, Fully Automated Radiotherapy Treatment Planning System

Radiation Planning Assistant - A Streamlined, Fully Automated Radiotherapy Treatment Planning System

Published on: April 11, 2018

Validating knowledge-based volumetric modulated arc therapy plans with a multi-institution model (broad model) using

Takaaki Ito^1,2, Kazuki Kubo¹, Ryuta Nakahara³

¹Department of Medical Physics, Graduate School of Medical Sciences, Kindai University, 377-2 Onohigashi, Osakasayama-shi, Osaka, 589-8511, Japan.

Physical and Engineering Sciences in Medicine

|December 18, 2024

Summary

A broad model for prostate cancer volumetric modulated arc therapy (VMAT) plans (KBP_broad) effectively reduced organ-at-risk doses compared to institutional models and clinical plans. This demonstrates KBP_broad

Keywords:

Broad model Complete open-loop validation Knowledge-based planning Volumetric modulated arc therapy

More Related Videos

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Published on: February 6, 2019

Positron Emission Tomography-based Dose Painting Radiation Therapy in a Glioblastoma Rat Model using the Small Animal Radiation Research Platform

Positron Emission Tomography-based Dose Painting Radiation Therapy in a Glioblastoma Rat Model using the Small Animal Radiation Research Platform

Published on: March 24, 2022

Related Experiment Videos

Last Updated: May 2, 2026

Radiation Planning Assistant - A Streamlined, Fully Automated Radiotherapy Treatment Planning System

Radiation Planning Assistant - A Streamlined, Fully Automated Radiotherapy Treatment Planning System

Published on: April 11, 2018

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Published on: February 6, 2019

Positron Emission Tomography-based Dose Painting Radiation Therapy in a Glioblastoma Rat Model using the Small Animal Radiation Research Platform

Positron Emission Tomography-based Dose Painting Radiation Therapy in a Glioblastoma Rat Model using the Small Animal Radiation Research Platform

Published on: March 24, 2022

Area of Science:

Radiation Oncology
Medical Physics
Cancer Treatment Planning

Background:

Volumetric Modulated Arc Therapy (VMAT) is a sophisticated radiation technique for prostate cancer treatment.
Developing generalized models for VMAT plan quality is challenging due to institutional variations in treatment protocols.
Knowledge-based planning (KBP) models aim to automate and optimize radiation therapy planning.

Purpose of the Study:

To evaluate the clinical effectiveness of a broad, multi-institutional KBP model (KBP_broad) for prostate cancer VMAT plans.
To compare the quality of plans generated by KBP_broad against institutional-specific KBP models (KBP_onsite) and clinical plans (CPs).
To assess KBP_broad's performance across different institutions with varying treatment protocols.

Main Methods:

A KBP_broad model was trained on 561 prostate cancer VMAT plans from five institutions.
An open-loop evaluation was conducted at two independent institutions using 30 patient cases each.
Plans generated by KBP_broad were compared to CPs and KBP_onsite plans based on target coverage and organ-at-risk (OAR) dose constraints.

Main Results:

KBP_broad maintained target coverage comparable to CPs while meeting dose constraints.
At institution X, KBP_broad significantly reduced rectal wall dose volumes (V_40Gy, V_60Gy, V_70Gy) compared to KBP_onsite and CPs.
At institution Y, KBP_broad demonstrated superior dose homogeneity and conformality for the planning target volume and improved OAR sparing compared to CPs.

Conclusions:

The broad KBP model (KBP_broad) is clinically effective and can improve VMAT plan quality, particularly at institutions with less optimized OAR dose reduction.
KBP_broad offers a viable solution for enhancing VMAT planning consistency and quality across diverse clinical settings.
The study validates the potential of generalized KBP models to outperform single-institution models and standard clinical practices.