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Updated: Jun 4, 2025

Spatio-Temporal Manipulation of Small GTPase Activity at Subcellular Level and on Timescale of Seconds in Living Cells
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Ionic control of small GTPase HRas using calmodulin.

Yassine Sabek1, Ziyun Zhang1, Nobuyuki Nishibe1

  • 1Department of Biosciences, Graduate School of Science and Engineering, Soka University, 1-236 Tangi-cho, Hachioji, Tokyo 192-8577, Japan.

Journal of Biochemistry
|December 19, 2024
PubMed
Summary

Engineered HRas fusion proteins, M13-HRas-M13, offer enhanced calcium-dependent control over GTPase activity and interactions with downstream signaling partners like Raf and GEF.

Keywords:
HRascalcium ioncalmodulinionic controlsmall GTPase

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