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Related Experiment Video

Updated: Jun 4, 2025

Assessment of Global Ocular Structure Following Spaceflight Using a Micro-Computed Tomography Micro-CT Imaging Method
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Ocular Biomechanical Responses to Long-Duration Spaceflight.

Marisse Masis Solano1,2, Remy Dumas1, Mark R Lesk1,2

  • 1Maisonneuve-Rosemont Hospital Research Center Montreal QC H1T 2M4 Canada.

IEEE Open Journal of Engineering in Medicine and Biology
|December 19, 2024
PubMed
Summary
This summary is machine-generated.

Long-term space missions significantly decrease ocular rigidity, intraocular pressure, and ocular pulse amplitude. These changes in ocular biomechanics may serve as biomarkers for Spaceflight-Associated Neuro-ocular Syndrome (SANS).

Keywords:
Microgravityocular rigidityspace biomechanicsspaceflight

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Area of Science:

  • Ophthalmology
  • Space Medicine
  • Biophysics

Background:

  • Spaceflight-Associated Neuro-ocular Syndrome (SANS) is a condition affecting astronauts.
  • Understanding the ocular effects of microgravity is crucial for astronaut health.
  • Ocular biomechanics, including ocular rigidity (OR), intraocular pressure (IOP), and ocular pulse amplitude (OPA), are key parameters.

Purpose of the Study:

  • To investigate the impact of long-duration space missions on ocular rigidity, intraocular pressure, and ocular pulse amplitude.
  • To evaluate changes in ocular biomechanical properties in astronauts post-flight.

Main Methods:

  • Ocular rigidity (OR) assessed using optical coherence tomography (OCT) and deep learning-based choroid segmentation.
  • Intraocular pressure (IOP) and ocular pulse amplitude (OPA) measured with the PASCAL Dynamic Contour Tonometer (DCT).
  • Study involved 13 astronauts with 157-186 days on the International Space Station.

Main Results:

  • A significant 33% reduction in ocular rigidity (OR) was observed post-mission (p = 0.04).
  • Intraocular pressure (IOP) decreased by 11% (from 16.0 to 14.2 mmHg, p = 0.04).
  • Ocular pulse amplitude (OPA) showed a 25% decrease (p < 0.005).

Conclusions:

  • Long-term microgravity exposure significantly alters the eye's mechanical properties.
  • These findings provide new insights into the pathophysiology of SANS.
  • Changes in ocular biomechanics may serve as potential biomarkers for SANS progression.